Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 6/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 2/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.37 |
| ▸ | F13A1 | P00488 | 1/20 | 0.36 |
| ▸ | TGM2 | P21980 | 1/20 | 0.36 |
| ▸ | TGM1 | P22735 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3496751 | 1.00 | GAA (0.44) | GAAGPR119NR1H2NR1H3HDAC1 | |
| SCHEMBL3496752 | 1.00 | GAA (0.44) | GAAGPR119NR1H2NR1H3HDAC1 | |
| SCHEMBL1015285 | 1.00 | GAA (0.44) | GAAGPR119NR1H2NR1H3HDAC1 | |
| SCHEMBL1017414 | 0.90 | GPR119 (0.42) | GPR119NR1H2NR1H3HDAC1HSD11B1 | |
| SCHEMBL1017413 | 0.90 | GPR119 (0.42) | GPR119NR1H2NR1H3HDAC1HSD11B1 | |
| SCHEMBL1017415 | 0.90 | GPR119 (0.42) | GPR119NR1H2NR1H3HDAC1HSD11B1 | |
| SCHEMBL1015650 | 0.89 | GPR119 (0.42) | GPR119NR1H2NR1H3HDAC1HSD11B1 | |
| SCHEMBL1015653 | 0.89 | GPR119 (0.42) | GPR119NR1H2NR1H3HDAC1HSD11B1 | |
| SCHEMBL1015651 | 0.89 | GPR119 (0.42) | GPR119NR1H2NR1H3HDAC1HSD11B1 | |
| SCHEMBL3495707 | 0.88 | GPR119 (0.43) | GPR119NR1H2NR1H3HDAC1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271649-A1 | BRIDGED, BICYCLIC HETEROCYCLIC OR SPIRO BICYCLIC HETEROCYCLIC DERIVATIVES OF PYRAZOLO[1,5-A]PYRIMIDINES, METHODS FOR PREPARATION AND USES THEREOF | Wyeth LLC (US) | 2011-01-12 | — | — | EP | disclosed |