Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 6/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 2/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.37 |
| ▸ | F13A1 | P00488 | 1/20 | 0.36 |
| ▸ | TGM2 | P21980 | 1/20 | 0.36 |
| ▸ | TGM1 | P22735 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3496751 | 1.00 | GAA (0.44) | GAAGPR119NR1H2NR1H3HDAC1 | |
| SCHEMBL1016375 | 1.00 | GAA (0.44) | GAAGPR119NR1H2NR1H3HDAC1 | |
| SCHEMBL1015285 | 1.00 | GAA (0.44) | GAAGPR119NR1H2NR1H3HDAC1 | |
| SCHEMBL1017414 | 0.90 | GPR119 (0.42) | GPR119NR1H2NR1H3HDAC1HSD11B1 | |
| SCHEMBL1017413 | 0.90 | GPR119 (0.42) | GPR119NR1H2NR1H3HDAC1HSD11B1 | |
| SCHEMBL1017415 | 0.90 | GPR119 (0.42) | GPR119NR1H2NR1H3HDAC1HSD11B1 | |
| SCHEMBL1015650 | 0.89 | GPR119 (0.42) | GPR119NR1H2NR1H3HDAC1HSD11B1 | |
| SCHEMBL1015653 | 0.89 | GPR119 (0.42) | GPR119NR1H2NR1H3HDAC1HSD11B1 | |
| SCHEMBL1015651 | 0.89 | GPR119 (0.42) | GPR119NR1H2NR1H3HDAC1HSD11B1 | |
| SCHEMBL3495707 | 0.88 | GPR119 (0.43) | GPR119NR1H2NR1H3HDAC1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029657-A1 | Bridged, Bicyclic Heterocyclic or Spiro Bicyclic Heterocyclic Derivatives of Pyrazolo[1, 5-A]Pyrimidines, Methods for Preparation and Uses Thereof | WYETH (US) | 2010-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029657-A1 | Bridged, Bicyclic Heterocyclic or Spiro Bicyclic Heterocyclic Derivatives of Pyrazolo[1, 5-A]Pyrimidines, Methods for Preparation and Uses Thereof | BRAF, RAF1, ARAF | GAA 3676/4885GPR119 2939/4885NR1H2 3723/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.