Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10165480 | 1.00 | L3MBTL1 (0.56) | L3MBTL1MEN1KMT2ATDP1MAPT | |
| SCHEMBL10165527 | 1.00 | L3MBTL1 (0.56) | L3MBTL1MEN1KMT2ATDP1MAPT | |
| SCHEMBL10175709 | 0.81 | KDM4E (0.61) | L3MBTL1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL10165579 | 0.81 | MEN1 (0.62) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL10165501 | 0.81 | MEN1 (0.62) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL10165447 | 0.81 | MEN1 (0.62) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL10065686 | 0.76 | MAPT (0.50) | L3MBTL1MAPTALDH1A1KDM4ENPSR1 | |
| SCHEMBL15113254 | 0.73 | MEN1 (0.81) | L3MBTL1MEN1KMT2ATDP1ALDH1A1 | |
| SCHEMBL135654 | 0.72 | SMN1; SMN2 (0.67) | MEN1KMT2AALDH1A1LMNAKDM4E | |
| SCHEMBL10175699 | 0.72 | ALDH1A1 (0.66) | L3MBTL1MAPTALDH1A1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8193194-B2 | Ion channel modulators and methods of use | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-06-05 | — | — | US | disclosed |
| US-8193194-B2 | Ion channel modulators and methods of use | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-06-05 | — | — | US | disclosed |