Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C2 | P52895 | 1/20 | 0.74 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.59 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.59 |
| ▸ | HTR1D | P28221 | 2/20 | 0.58 |
| ▸ | HTR6 | P50406 | 2/20 | 0.58 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
| ▸ | HTR1E | P28566 | 1/20 | 0.55 |
| ▸ | HTR7 | P34969 | 1/20 | 0.55 |
| ▸ | HTR5A | P47898 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Deschlorobenzoyl Indomethacin SCHEMBL454792 | 0.85 | AKR1C2 (1.00) | AKR1C2MTNR1AMTNR1BHTR1DHTR6 | |
| SCHEMBL10205891 | 0.85 | AKR1C2 (0.80) | AKR1C2MTNR1AMTNR1BHTR1DHTR6 | |
| SCHEMBL8681515 | 0.84 | AKR1C2 (0.78) | AKR1C2MTNR1AMTNR1BHTR1DHTR6 | |
| SCHEMBL30604527 | 0.84 | AKR1C2 (0.78) | AKR1C2MTNR1AMTNR1BHTR1DHTR6 | |
| SCHEMBL6825151 | 0.84 | AKR1C2 (0.78) | AKR1C2MTNR1AMTNR1BHTR1DHTR6 | |
| SCHEMBL4245648 | 0.84 | AKR1C2 (0.78) | AKR1C2MTNR1AMTNR1BHTR1DHTR6 | |
| Deboxamet SCHEMBL29387753 | 0.82 | AKR1C2 (0.74) | AKR1C2MTNR1AMTNR1BHTR1DHTR6 | |
| SCHEMBL8270880 | 0.82 | AKR1C2 (0.74) | AKR1C2MTNR1AMTNR1BHTR1DHTR6 | |
| Deboxamet SCHEMBL186946 | 0.82 | AKR1C2 (0.74) | AKR1C2MTNR1AMTNR1BHTR1DHTR6 | |
| SCHEMBL5605077 | 0.82 | AKR1C2 (0.74) | AKR1C2MTNR1AMTNR1BHTR1DHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120035194-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | PFIZER INC. (US) | 2012-02-09 | — | — | US | disclosed |
| US-7998978-B2 | Substituted 2-amino-fused heterocyclic compounds | PFIZER INC. (US) | 2011-08-16 | — | — | US | disclosed |
| US-20100056506-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035194-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | MAPK1, SLC5A1, ATF1 | AKR1C2 250/4885MTNR1A 207/4885MTNR1B 228/4885 |
| US-20100056506-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | MAPK1, SLC5A1, ATF1 | AKR1C2 250/4885MTNR1A 207/4885MTNR1B 228/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.