Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C2 | P52895 | 1/20 | 0.78 |
| ▸ | HTR1D | P28221 | 2/20 | 0.64 |
| ▸ | HTR6 | P50406 | 2/20 | 0.64 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.62 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.62 |
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.58 |
| ▸ | HTR1E | P28566 | 1/20 | 0.58 |
| ▸ | HTR7 | P34969 | 1/20 | 0.58 |
| ▸ | HTR5A | P47898 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7956382 | 0.89 | AKR1C2 (0.61) | AKR1C2HTR1DHTR6MTNR1AMTNR1B | |
| Deschlorobenzoyl Indomethacin SCHEMBL454792 | 0.87 | AKR1C2 (1.00) | AKR1C2HTR1DHTR6MTNR1AMTNR1B | |
| SCHEMBL10205891 | 0.87 | AKR1C2 (0.80) | AKR1C2HTR1DHTR6MTNR1AMTNR1B | |
| SCHEMBL6825151 | 0.86 | AKR1C2 (0.78) | AKR1C2HTR1DHTR6MTNR1AMTNR1B | |
| SCHEMBL8681515 | 0.86 | AKR1C2 (0.78) | AKR1C2HTR1DHTR6MTNR1AMTNR1B | |
| SCHEMBL30604527 | 0.86 | AKR1C2 (0.78) | AKR1C2HTR1DHTR6MTNR1AMTNR1B | |
| Deboxamet SCHEMBL29387753 | 0.84 | AKR1C2 (0.74) | AKR1C2HTR1DHTR6MTNR1AMTNR1B | |
| Deboxamet SCHEMBL186946 | 0.84 | AKR1C2 (0.74) | AKR1C2HTR1DHTR6MTNR1AMTNR1B | |
| SCHEMBL10165841 | 0.84 | AKR1C2 (0.74) | AKR1C2HTR1DHTR6MTNR1AMTNR1B | |
| SCHEMBL8270880 | 0.84 | AKR1C2 (0.74) | AKR1C2HTR1DHTR6MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116710434-A | Modulators of MAS-related G protein receptor X2 and related products and uses thereof | 伊赛恩特制药公司 | 2023-09-05 | — | — | CN | disclosed |
| US-9850183-B2 | Conjugates derived from non-steroidal anti-inflammatory drugs and methods of use thereof in imaging | Reiley Pharmaceuticals, Inc. (US) | 2017-12-26 | — | — | US | disclosed |
| US-20140364415-A1 | PYRROLO[2,3-d]PYRIMIDINE TROPOMYSIN-RELATED KINASE INHIBITORS | PFIZER LIMITED (GB) | 2014-12-11 | — | — | US | disclosed |
| US-8846698-B2 | Pyrrolo[2,3-d]pyrimidine tropomysin-related kinase inhibitors | PFIZER LIMITED (US) | 2014-09-30 | — | — | US | disclosed |
| WO-2014067985-A1 | COMPOUNDS FOR USE IN THE TREATMENT OF PARASITIC DISEASES | IRBM SCIENCE PARK S.P.A. (IT) | 2014-05-08 | — | — | WO | disclosed |
| US-20120258950-A1 | PYRROLO[2,3-d]PYRIMIDINE TROPOMYSIN-RELATED KINASE INHIBITORS | PFIZER LIMITED (GB) | 2012-10-11 | — | — | US | disclosed |
| US-7666898-B2 | Multivalent indole compounds and use thereof as phospholipase-A2 inhibitors | ILYPSA, INC. (US) | 2010-02-23 | — | — | US | disclosed |
| US-7666898-B2 | Multivalent indole compounds and use thereof as phospholipase-A2 inhibitors | ILYPSA, INC. (US) | 2010-02-23 | — | — | US | disclosed |
| US-20090252678-A1 | COX-2-TARGETED IMAGING AGENTS | VANDERBILT UNIVERSITY (US) | 2009-10-08 | — | — | US | disclosed |
| US-20080051447-A1 | Treatment Of Hypercholesterolemia, Hypertriglyceridemia And Cardiovascular-Related Conditions Using Phospholipase-A2 Inhibitors | ILYPSA, INC. | 2008-02-28 | — | — | US | disclosed |
| EP-1638612-A2 | COX-2-TARGETED IMAGING AGENTS | Vanderbilt University (US) | 2006-03-29 | — | — | EP | disclosed |
| US-20050215495-A1 | Macrolide antibiotics | ALIHODZIC SULEJMAN | 2005-09-29 | — | — | US | disclosed |
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | TAISHO PHARMACEUTICAL CO., LTD. | 2005-09-08 | — | — | US | disclosed |
| US-20050002859-A1 | COX-2-targeted imaging agents | VANDERBILT UNIVERSITY (US) | 2005-01-06 | — | — | US | disclosed |
| WO-2005002293-A2 | COX-2-TARGETED IMAGING AGENTS | VANDERBILT UNIVERSITY (US) | 2005-01-06 | — | — | WO | disclosed |
| EP-1225882-A4 | SELECTIVE COX-2 INHIBITORY NOVEL ESTERS FROM INDOLEALKANOLS AND NOVEL AMIDES FROM INDOLEALKYLAMINES | UNIV VANDERBILT (US) | 2004-12-29 | — | — | EP | disclosed |
| US-20040077557-A1 | Macrolide antibiotics | GLAXO GROUP LIMITED (GB) | 2004-04-22 | — | — | US | disclosed |
| EP-1225882-A1 | SELECTIVE COX-2 INHIBITORY NOVEL ESTERS FROM INDOLEALKANOLS AND NOVEL AMIDES FROM INDOLEALKYLAMINES | Vanderbilt University (US) | 2002-07-31 | — | — | EP | disclosed |
| US-6306890-B1 | COMPOUNDS FOR INHIBITING CYCLOOXYGENASE | VANDERBILT UNIVERSITY | 2001-10-23 | — | — | US | disclosed |
| WO-2001015686-A1 | SELECTIVE COX-2 INHIBITORY NOVEL ESTERS FROM INDOLEALKANOLS AND NOVEL AMIDES FROM INDOLEALKYLAMINES | VANDERBILT UNIVERSITY (US) | 2001-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050215495-A1 | Macrolide antibiotics | IL1R1, MRPL12, RPS21 | AKR1C2 52/4885HTR1D 1831/4885HTR6 4634/4885 |
| US-20140364415-A1 | PYRROLO[2,3-d]PYRIMIDINE TROPOMYSIN-RELATED KINASE INHIBITORS | DMPK, DTYMK, MUSK | AKR1C2 3730/4885HTR1D 1518/4885HTR6 2015/4885 |
| US-20050002859-A1 | COX-2-targeted imaging agents | PTGS2, PTGES2, PTGER2 | AKR1C2 2409/4885HTR1D 2418/4885HTR6 472/4885 |
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | HCRTR2, MCHR1, MCHR2 | AKR1C2 3644/4885HTR1D 122/4885HTR6 148/4885 |
| US-20120258950-A1 | PYRROLO[2,3-d]PYRIMIDINE TROPOMYSIN-RELATED KINASE INHIBITORS | DMPK, DTYMK, MUSK | AKR1C2 3730/4885HTR1D 1518/4885HTR6 2015/4885 |
| US-20040077557-A1 | Macrolide antibiotics | MALT1, MRPL21, IL1R1 | AKR1C2 131/4885HTR1D 942/4885HTR6 4376/4885 |
| US-20090252678-A1 | COX-2-TARGETED IMAGING AGENTS | PTGS2, PTGES2, PTGER2 | AKR1C2 2409/4885HTR1D 2418/4885HTR6 472/4885 |
| US-20080051447-A1 | Treatment Of Hypercholesterolemia, Hypertriglyceridemia And Cardiovascular-Related Conditions Using Phospholipase-A2 Inhibitors | PNLIP, PLA2G1B, PLA2G4A | AKR1C2 1166/4885HTR1D 1342/4885HTR6 1021/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.