Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT3A | P56704 | 1/20 | 0.59 |
| ▸ | DYRK1A | Q13627 | 9/20 | 0.56 |
| ▸ | GSK3B | P49841 | 8/20 | 0.56 |
| ▸ | WNT1 | P04628 | 5/20 | 0.56 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.53 |
| ▸ | RIOK2 | Q9BVS4 | 6/20 | 0.52 |
| ▸ | GSK3A | P49840 | 3/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.52 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.52 |
| ▸ | SNRK | Q9NRH2 | 1/20 | 0.52 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.49 |
| ▸ | CLK2 | P49760 | 1/20 | 0.47 |
| ▸ | CLK3 | P49761 | 1/20 | 0.47 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.46 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10165889 | 0.86 | MAPK8 (0.72) | WNT3ADYRK1AGSK3BWNT1MAPK8 | |
| SCHEMBL560081 | 0.86 | WNT3A (0.59) | WNT3ADYRK1AGSK3BWNT1MAPK8 | |
| SCHEMBL12361579 | 0.78 | WNT3A (0.57) | WNT3ADYRK1AGSK3BWNT1MAPK8 | |
| SCHEMBL12303086 | 0.78 | WNT3A (0.83) | WNT3ADYRK1AGSK3BWNT1MAPK8 | |
| SCHEMBL559024 | 0.76 | DYRK1A (0.65) | WNT3ADYRK1AGSK3BWNT1MAPK8 | |
| SCHEMBL1722613 | 0.74 | WNT3A (1.00) | WNT3ADYRK1AGSK3BWNT1RIOK2 | |
| SCHEMBL10165892 | 0.74 | GSK3B (0.47) | DYRK1AGSK3BWNT1 | |
| SCHEMBL10165891 | 0.73 | MAPK8 (0.53) | DYRK1AGSK3BWNT1MAPK8 | |
| SCHEMBL559364 | 0.73 | MAPK8 (0.70) | WNT3ADYRK1AGSK3BWNT1MAPK8 | |
| SCHEMBL19517223 | 0.72 | WNT1 (1.00) | DYRK1AGSK3BWNT1MAPK8CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120035194-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | PFIZER INC. (US) | 2012-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035194-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | MAPK1, SLC5A1, ATF1 | WNT3A 1899/4885DYRK1A 1064/4885GSK3B 685/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.