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SCHEMBL10166855

SCHEMBL10166855

C[C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)O)C1CCCCC1)N(C)C(=O)OC(C)(C)C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ACE P12821 7/20 0.40
▸ REN P00797 4/20 0.40
▸ KDM4E B2RXH2 1/20 0.40
▸ F2 P00734 1/20 0.40
▸ LMNA P02545 1/20 0.40
▸ LTA4H P09960 1/20 0.40
▸ MAPT P10636 1/20 0.40
▸ PEPD P12955 1/20 0.40
▸ ALOX15 P16050 1/20 0.40
▸ PTGS1 P23219 1/20 0.40
▸ HTR2A P28223 1/20 0.40
▸ PTGS2 P35354 1/20 0.40
▸ HRH1 P35367 1/20 0.40
▸ THPO P40225 1/20 0.40
▸ PMP22 Q01453 1/20 0.40
▸ HSD17B10 Q99714 1/20 0.40
▸ ACE2 Q9BYF1 1/20 0.40
▸ BIRC2 Q13490 5/20 0.38
▸ XIAP P98170 1/20 0.37
▸ BIRC3 Q13489 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28680937 1.00 ACE (0.40) ACERENKDM4EF2LMNA
SCHEMBL20681620 1.00 ACE (0.40) ACERENKDM4EF2LMNA
SCHEMBL28619551 1.00 ACE (0.40) ACERENKDM4EF2LMNA
SCHEMBL10167020 0.91 BIRC2 (0.37) F2BIRC2XIAPBIRC3
SCHEMBL28604275 0.91 PEPD (0.39) F2LMNAPEPDBIRC2XIAP
SCHEMBL25092400 0.91 PEPD (0.39) F2LMNAPEPDBIRC2XIAP
SCHEMBL10166931 0.90 BIRC2 (0.42) F2BIRC2XIAPBIRC3
SCHEMBL28370502 0.90 ACE (0.38) ACERENKDM4EF2LMNA
SCHEMBL28370504 0.90 ACE (0.38) ACERENKDM4EF2LMNA
SCHEMBL1163393 0.86 XIAP (0.49) BIRC2XIAPBIRC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11963994-B2 Inhibitors of IAP GENENTECH, INC. (US) 2024-04-23 — — US disclosed
US-20230067037-A1 CONJUGATED CHEMICAL INDUCERS OF DEGRADATION AND METHODS OF USE GENENTECH, INC. (US) 2023-03-02 — — US disclosed
US-20220220152-A1 BIVALENT ANTAGONISTS OF INHIBITORS OF APOPTOSIS PROTEINS Hepagene Therapeutics (HK) Limited (HK) 2022-07-14 — — US disclosed
US-20220211797-A1 INHIBITORS OF IAP GENENTECH, INC. (US) 2022-07-07 — — US disclosed
US-20210371459-A1 DIMERIC PEPTIDE INHIBITORS OF APOPTOSIS PROTEINS Hepagene Therapeutics (HK) Limited (HK) 2021-12-02 — — US disclosed
CN-113677399-A Bivalent antagonists of inhibitor of apoptosis proteins 和博医药有限公司 2021-11-19 — — CN disclosed
CN-113056287-A Conjugated chemical degradation inducers and methods of use 豪夫迈·罗氏有限公司 2021-06-29 — — CN disclosed
US-20170136084-A1 INHIBITORS OF IAP GENENTECH, INC. (US) 2017-05-18 — — US disclosed
US-9586991-B2 Inhibitors of IAP GENENTECH, INC. (US) 2017-03-07 — — US disclosed
US-20160102119-A1 INHIBITORS OF IAP GENENTECH, INC. (US) 2016-04-14 — — US disclosed
US-20130172264-A1 INHIBITORS OF IAP GENENTECH, INC. (US) 2013-07-04 — — US disclosed
US-20120202750-A1 INHIBITORS OF IAP GENENTECH, INC. (US) 2012-08-09 — — US disclosed
US-8110568-B2 Inhibitors of IAP GENENTECH, INC. (US) 2012-02-07 — — US disclosed
US-8110568-B2 Inhibitors of IAP GENENTECH, INC. (US) 2012-02-07 — — US disclosed
US-20110269696-A1 INHIBITORS OF IAPS GENENTECH INC. (US) 2011-11-03 — — US disclosed
US-20100256115-A1 INHIBITORS OF IAP COHEN FREDERICK 2010-10-07 — — US disclosed
US-20100256115-A1 INHIBITORS OF IAP COHEN FREDERICK 2010-10-07 — — US disclosed
WO-2010017035-A2 INHIBITORS OF IAP GENENTECH, INC. (US) 2010-02-11 — — WO disclosed
US-20070299052-A1 Inhibitors of IAP GENENTECH, INC. (US) 2007-12-27 — — US disclosed
US-7244851-B2 1-[2-Cyclohexyl-2-(2-methylamino-propionylamino)-acetyl]-pyrrolidine-2-carboxylic acid (2-phenyl-2H-pyrazol-3-yl)-amide; inhibitors of IAP, for treating malignancies GENENTECH, INC. (US) 2007-07-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170136084-A1 INHIBITORS OF IAP BIRC5, XIAP, BIRC3 ACE 1370/4885REN 1182/4885KDM4E 3249/4885
US-20130172264-A1 INHIBITORS OF IAP BIRC5, XIAP, BIRC3 ACE 1370/4885REN 1182/4885KDM4E 3249/4885
US-20210371459-A1 DIMERIC PEPTIDE INHIBITORS OF APOPTOSIS PROTEINS BIRC2, BIRC5, BIRC3 ACE 2530/4885REN 3978/4885KDM4E 4694/4885
US-20230067037-A1 CONJUGATED CHEMICAL INDUCERS OF DEGRADATION AND METHODS OF USE ADRM1, SSB, FCER2 ACE 3135/4885REN 4235/4885KDM4E 2623/4885
US-20110269696-A1 INHIBITORS OF IAPS XIAP, BIRC5, BIRC3 ACE 649/4885REN 926/4885KDM4E 3032/4885
US-20070299052-A1 Inhibitors of IAP XIAP, BIRC5, BIRC3 ACE 1088/4885REN 999/4885KDM4E 2538/4885
US-20160102119-A1 INHIBITORS OF IAP BIRC5, XIAP, BIRC3 ACE 1370/4885REN 1182/4885KDM4E 3249/4885
US-20120202750-A1 INHIBITORS OF IAP XIAP, BIRC5, BIRC3 ACE 1088/4885REN 999/4885KDM4E 2538/4885
US-20220211797-A1 INHIBITORS OF IAP BIRC5, XIAP, BIRC3 ACE 1370/4885REN 1182/4885KDM4E 3249/4885
US-20100256115-A1 INHIBITORS OF IAP XIAP, BIRC5, BIRC3 ACE 1088/4885REN 999/4885KDM4E 2538/4885
US-11963994-B2 Inhibitors of IAP BIRC5, XIAP, BIRC3 ACE 1370/4885REN 1182/4885KDM4E 3249/4885
US-20220220152-A1 BIVALENT ANTAGONISTS OF INHIBITORS OF APOPTOSIS PROTEINS BIRC5, BIRC2, BIRC3 ACE 2581/4885REN 3326/4885KDM4E 3883/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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