Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 2/20 | 0.34 |
| ▸ | BTK | Q06187 | 6/20 | 0.34 |
| ▸ | EZH2 | Q15910 | 2/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
| ▸ | CTSE | P14091 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.32 |
| ▸ | STS | P08842 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL483566 | 0.87 | KCNH2 (0.49) | OPRK1BTKEZH2GPR119KCNH2 | |
| SCHEMBL1107916 | 0.87 | EZH2 (0.43) | OPRK1KDM1ABTKEZH2GPR119 | |
| SCHEMBL28285321 | 0.84 | GPR119 (0.43) | KDM1AGPR119RORC | |
| SCHEMBL10167514 | 0.84 | KCNH2 (0.42) | BTKKCNH2MAOB | |
| SCHEMBL1104538 | 0.81 | GPR119 (0.37) | KDM1AGPR119RORCMAOAMAOB | |
| SCHEMBL310810 | 0.81 | GPR119 (0.37) | KDM1AGPR119RORCMAOAMAOB | |
| SCHEMBL484710 | 0.81 | YAP1 (0.46) | KCNH2MAOB | |
| SCHEMBL311656 | 0.81 | YAP1 (0.46) | KCNH2MAOB | |
| SCHEMBL310675 | 0.78 | KCNH2 (0.55) | BTKKCNH2MAOB | |
| SCHEMBL483793 | 0.78 | KCNH2 (0.55) | BTKKCNH2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934176-B1 | QUATERNARY ALPHA-AMINOCARBOXAMIDE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED SODIUM CHANNELS | GLAXO GROUP LTD (GB) | 2012-02-01 | — | — | EP | disclosed |
| WO-2007042240-A1 | QUATERNARY ALPHA-AMINOCARBOXAMIDE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED SODIUM CHANNELS | GLAXO GROUP LIMITED (GB) | 2007-04-19 | — | — | WO | disclosed |