Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 1/20 | 0.50 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.50 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 2/20 | 0.35 |
| ▸ | SPR | P35270 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | BUB1 | O43683 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.31 |
| ▸ | RXRA | P19793 | 2/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21238736 | 1.00 | GRIN2B (0.50) | GRIN2BGRIN2CJAK3KDM4EMAPT | |
| SCHEMBL22975107 | 0.96 | GRIN2B (0.46) | GRIN2BGRIN2CJAK3KDM4EMAPT | |
| SCHEMBL2304050 | 0.94 | GRIN2B (0.50) | GRIN2BGRIN2CJAK3KDM4EMAPT | |
| SCHEMBL21238799 | 0.93 | GRIN2B (0.46) | GRIN2BGRIN2CJAK3KDM4EMAPT | |
| SCHEMBL19852919 | 0.90 | GRIN2B (0.46) | GRIN2BGRIN2CJAK3KDM4EMAPT | |
| SCHEMBL15936936 | 0.87 | GRIN2B (0.51) | GRIN2BGRIN2CJAK3KDM4EMAPT | |
| SCHEMBL31401367 | 0.86 | GRIN2B (0.41) | GRIN2BGRIN2CJAK3KDM4EMAPT | |
| SCHEMBL24436783 | 0.84 | GRIN2B (0.51) | GRIN2BGRIN2CJAK3KDM4EMAPT | |
| SCHEMBL9948870 | 0.83 | GRIN2B (0.40) | GRIN2BGRIN2CJAK3KDM4EMAPT | |
| SCHEMBL21224815 | 0.82 | GRIN2B (0.46) | GRIN2BGRIN2CJAK3KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934176-B1 | QUATERNARY ALPHA-AMINOCARBOXAMIDE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED SODIUM CHANNELS | GLAXO GROUP LTD (GB) | 2012-02-01 | — | — | EP | disclosed |