Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | BUB1 | O43683 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | CCNC | P24863 | 2/20 | 0.33 |
| ▸ | CDK8 | P49336 | 2/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.32 |
| ▸ | RXRA | P19793 | 2/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2304050 | 0.92 | GRIN2B (0.50) | GRIN2BGRIN2CCCR5MAPK1USP2 | |
| SCHEMBL19852919 | 0.90 | GRIN2B (0.46) | GRIN2BGRIN2CCCR5MAPK1USP2 | |
| SCHEMBL9948870 | 0.89 | GRIN2B (0.40) | GRIN2BGRIN2CCCR5MAPK1USP2 | |
| SCHEMBL10167279 | 0.86 | GRIN2B (0.50) | GRIN2BGRIN2CCCR5MAPK1USP2 | |
| SCHEMBL21238736 | 0.86 | GRIN2B (0.50) | GRIN2BGRIN2CCCR5MAPK1USP2 | |
| SCHEMBL22975107 | 0.85 | GRIN2B (0.46) | GRIN2BGRIN2CCCR5MAPK1USP2 | |
| SCHEMBL21238799 | 0.85 | GRIN2B (0.46) | GRIN2BGRIN2CCCR5MAPK1USP2 | |
| SCHEMBL15936936 | 0.78 | GRIN2B (0.51) | GRIN2BGRIN2CCCR5MAPK1USP2 | |
| SCHEMBL24436783 | 0.78 | GRIN2B (0.51) | GRIN2BGRIN2CCCR5MAPK1USP2 | |
| SCHEMBL9948587 | 0.78 | KDM4E (0.38) | CCR5USP2KDM4EMAPTDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4739682-A1 | 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS | Janssen Pharmaceutica NV (BE) | 2026-05-13 | — | — | EP | disclosed |
| WO-2025008058-A1 | 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS | JANSSEN PHARMACEUTICA NV (BE) | 2025-01-09 | — | — | WO | disclosed |