Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.45 |
| ▸ | CDK1 | P06493 | 5/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.44 |
| ▸ | CDK9 | P50750 | 2/20 | 0.44 |
| ▸ | JAK3 | P52333 | 5/20 | 0.43 |
| ▸ | AURKA | O14965 | 4/20 | 0.43 |
| ▸ | JAK2 | O60674 | 4/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.43 |
| ▸ | LCK | P06239 | 4/20 | 0.43 |
| ▸ | FYN | P06241 | 4/20 | 0.43 |
| ▸ | LYN | P07948 | 4/20 | 0.43 |
| ▸ | RET | P07949 | 4/20 | 0.43 |
| ▸ | ROS1 | P08922 | 4/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.43 |
| ▸ | SRC | P12931 | 4/20 | 0.43 |
| ▸ | MARK3 | P27448 | 4/20 | 0.43 |
| ▸ | TYK2 | P29597 | 4/20 | 0.43 |
| ▸ | FLT4 | P35916 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL342369 | 0.85 | CDK1 (0.58) | EGFRCDK1CCNT1CCNB1CDK9 | |
| SCHEMBL31299861 | 0.82 | PTGS1 (0.52) | CDK1CCNT1CCNB1CDK9JAK3 | |
| SCHEMBL15428629 | 0.77 | CDK4 (0.48) | EGFRCDK1CCNT1CCNB1CDK9 | |
| SCHEMBL10167396 | 0.77 | CDK1 (0.41) | EGFRERBB2CDK1CCNT1CCNB1 | |
| SCHEMBL343868 | 0.77 | CDK1 (0.41) | EGFRERBB2CDK1CCNB1CDK9 | |
| SCHEMBL343043 | 0.77 | MERTK (0.42) | EGFRERBB2CDK1CCNB1JAK3 | |
| SCHEMBL343044 | 0.77 | MERTK (0.42) | EGFRERBB2CDK1CCNB1JAK3 | |
| SCHEMBL343867 | 0.77 | CDK1 (0.41) | EGFRERBB2CDK1CCNB1CDK9 | |
| SCHEMBL16570689 | 0.77 | PTK2 (0.52) | EGFRERBB2CDK1CCNT1CCNB1 | |
| SCHEMBL343790 | 0.77 | ABL1 (0.47) | EGFRERBB2JAK3FGFR1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8637529-B2 | Pyrazolo[3,4-d]pyrimidine compounds | AbbYie Inc. (US) | 2014-01-28 | — | — | US | disclosed |
| US-8637529-B2 | Pyrazolo[3,4-d]pyrimidine compounds | AbbYie Inc. (US) | 2014-01-28 | — | — | US | disclosed |
| US-20120015963-A1 | NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2012-01-19 | — | — | US | disclosed |
| US-20120015963-A1 | NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2012-01-19 | — | — | US | disclosed |
| WO-2011156698-A2 | NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2011-12-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015963-A1 | NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS | CHUK, MAP2K2, CDK3 | EGFR 3549/4885ERBB2 1369/4885CDK1 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.