Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 8/20 | 0.48 |
| ▸ | CCND1 | P24385 | 8/20 | 0.48 |
| ▸ | CCND2 | P30279 | 8/20 | 0.48 |
| ▸ | CCND3 | P30281 | 8/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 6/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.42 |
| ▸ | CDK9 | P50750 | 2/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.42 |
| ▸ | CDK2 | P24941 | 4/20 | 0.42 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.42 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.42 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL342369 | 0.83 | CDK1 (0.58) | PTK2CDK1CCNB1CCNT1CDK9 | |
| SCHEMBL31299861 | 0.81 | PTGS1 (0.52) | PTK2CDK1CCNB1CCNT1CDK9 | |
| SCHEMBL343790 | 0.81 | ABL1 (0.47) | CDK4CCND1CCND2CCND3PTK2 | |
| SCHEMBL10167382 | 0.80 | JAK3 (0.48) | PTK2JAK3JAK2TYK2ALK | |
| SCHEMBL16570689 | 0.78 | PTK2 (0.52) | PTK2CDK1CCNB1CCNT1CDK9 | |
| SCHEMBL343368 | 0.77 | CDK4 (0.51) | CDK4CCND1CCND2CCND3PTK2 | |
| SCHEMBL10167393 | 0.77 | EGFR (0.45) | PTK2CDK1CCNB1CCNT1CDK9 | |
| SCHEMBL344496 | 0.77 | CDK4 (0.62) | CDK4CCND1CCND2CCND3PTK2 | |
| SCHEMBL10167381 | 0.76 | NAMPT (0.54) | CDK1CCNB1CCNT1CDK9JAK3 | |
| SCHEMBL31299871 | 0.75 | PTGS2 (0.49) | CDK4CCND1CCND2CCND3PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8637529-B2 | Pyrazolo[3,4-d]pyrimidine compounds | AbbYie Inc. (US) | 2014-01-28 | — | — | US | claimed |