Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.52 |
| ▸ | CDK1 | P06493 | 4/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.47 |
| ▸ | CDK9 | P50750 | 2/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.46 |
| ▸ | JAK2 | O60674 | 3/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.45 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.45 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.42 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31299871 | 0.91 | PTGS2 (0.49) | PTGS1PTGS2CDK1CCNB1CCNT1 | |
| SCHEMBL342369 | 0.90 | CDK1 (0.58) | CDK1CCNB1CCNT1CDK9PTK2 | |
| SCHEMBL10167381 | 0.82 | NAMPT (0.54) | CDK1CCNB1CCNT1CDK9JAK2 | |
| SCHEMBL10167393 | 0.82 | EGFR (0.45) | CDK1CCNB1CCNT1CDK9PTK2 | |
| SCHEMBL15428629 | 0.81 | CDK4 (0.48) | CDK1CCNB1CCNT1CDK9PTK2 | |
| SCHEMBL10167382 | 0.80 | JAK3 (0.48) | PTK2JAK2JAK3 | |
| SCHEMBL344496 | 0.79 | CDK4 (0.62) | CDK1CCNB1PTK2JAK2FGFR4 | |
| SCHEMBL343790 | 0.79 | ABL1 (0.47) | PTK2ABL1BCRJAK3NR3C1 | |
| SCHEMBL343368 | 0.78 | CDK4 (0.51) | PTK2JAK2FGFR4AURKAJAK3 | |
| SCHEMBL16570689 | 0.77 | PTK2 (0.52) | CDK1CCNB1CCNT1CDK9PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024238570-A1 | CDK2 INHIBITOR PYRAZOLOPYRIMIDINE COMPOUNDS | ALEKSIA THERAPEUTICS, INC. (US) | 2024-11-21 | — | — | WO | disclosed |