Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 3/20 | 0.46 |
| ▸ | GHSR | Q92847 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 2/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10167532 | 0.93 | YAP1 (0.44) | YAP1GHSRPRMT5KCNH2LTA4H | |
| SCHEMBL13172547 | 0.89 | YAP1 (0.44) | YAP1GHSRPRMT5KCNH2LTA4H | |
| SCHEMBL1104530 | 0.89 | YAP1 (0.44) | YAP1GHSRPRMT5KCNH2LTA4H | |
| SCHEMBL1104560 | 0.89 | YAP1 (0.44) | YAP1GHSRPRMT5KCNH2LTA4H | |
| SCHEMBL14019388 | 0.89 | YAP1 (0.44) | YAP1GHSRPRMT5KCNH2LTA4H | |
| SCHEMBL1104543 | 0.87 | YAP1 (0.43) | YAP1GHSRPRMT5LTA4HADAM17 | |
| SCHEMBL1104528 | 0.87 | YAP1 (0.48) | YAP1GHSRPRMT5KCNH2ADAM17 | |
| SCHEMBL4770854 | 0.85 | PRMT5 (0.45) | YAP1GHSRPRMT5KCNH2TP53 | |
| SCHEMBL483258 | 0.85 | PRMT5 (0.45) | YAP1GHSRPRMT5KCNH2TP53 | |
| SCHEMBL311656 | 0.85 | YAP1 (0.46) | YAP1GHSRPRMT5KCNH2ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934176-B1 | QUATERNARY ALPHA-AMINOCARBOXAMIDE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED SODIUM CHANNELS | GLAXO GROUP LTD (GB) | 2012-02-01 | — | — | EP | disclosed |
| WO-2007042240-A1 | QUATERNARY ALPHA-AMINOCARBOXAMIDE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED SODIUM CHANNELS | GLAXO GROUP LIMITED (GB) | 2007-04-19 | — | — | WO | disclosed |