Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 8/20 | 0.45 |
| ▸ | YAP1 | P46937 | 3/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GHSR | Q92847 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4770854 | 1.00 | PRMT5 (0.45) | PRMT5YAP1KCNH2KDM4EMEN1 | |
| SCHEMBL484203 | 0.86 | YAP1 (0.45) | PRMT5YAP1KCNH2KDM4ETP53 | |
| SCHEMBL483518 | 0.86 | YAP1 (0.45) | PRMT5YAP1KCNH2KDM4ETP53 | |
| SCHEMBL483558 | 0.86 | YAP1 (0.45) | PRMT5YAP1KCNH2KDM4ETP53 | |
| Ethane SCHEMBL483694 | 0.86 | YAP1 (0.45) | PRMT5YAP1KCNH2KDM4ETP53 | |
| SCHEMBL483557 | 0.86 | YAP1 (0.45) | PRMT5YAP1KCNH2KDM4ETP53 | |
| SCHEMBL10167537 | 0.85 | YAP1 (0.46) | PRMT5YAP1KCNH2TP53GHSR | |
| SCHEMBL10167532 | 0.84 | YAP1 (0.44) | PRMT5YAP1KCNH2TP53GHSR | |
| SCHEMBL14019388 | 0.83 | YAP1 (0.44) | PRMT5YAP1KCNH2MAPTTP53 | |
| SCHEMBL1104560 | 0.83 | YAP1 (0.44) | PRMT5YAP1KCNH2TP53GHSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153623-B2 | Compounds | Convergence Pharmaceuticals Limited (GB) | 2012-04-10 | — | — | US | disclosed |
| EP-1934176-B1 | QUATERNARY ALPHA-AMINOCARBOXAMIDE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED SODIUM CHANNELS | GLAXO GROUP LTD (GB) | 2012-02-01 | — | — | EP | disclosed |