Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.49 |
| ▸ | KDM1A | O60341 | 2/20 | 0.47 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.46 |
| ▸ | CCR1 | P32246 | 2/20 | 0.46 |
| ▸ | CCR5 | P51681 | 2/20 | 0.46 |
| ▸ | CCR8 | P51685 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | METAP2 | P50579 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30572342 | 1.00 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1SYKKDM1APLA2G7 | |
| SCHEMBL13549952 | 0.86 | NPC1 (0.50) | SMN1; SMN2ALDH1A1SYKKDM1ACCR1 | |
| SCHEMBL16405693 | 0.83 | KDM4E (0.50) | SMN1; SMN2ALDH1A1KDM1ACCR1CCR5 | |
| SCHEMBL7576751 | 0.81 | CCR1 (0.53) | SMN1; SMN2ALDH1A1CCR1CCR5CCR8 | |
| SCHEMBL462513 | 0.81 | KDM1A (0.49) | SMN1; SMN2ALDH1A1KDM1ACCR1CCR5 | |
| SCHEMBL31558882 | 0.81 | KDM4E (0.56) | SMN1; SMN2ALDH1A1CCR1CCR5CCR8 | |
| Hydrochloric Acid SCHEMBL7085954 | 0.80 | KDM1A (0.48) | SMN1; SMN2ALDH1A1KDM1ACCR1CCR5 | |
| Hydrochloric Acid SCHEMBL7085964 | 0.80 | KDM1A (0.48) | SMN1; SMN2ALDH1A1KDM1ACCR1CCR5 | |
| Hydrochloric Acid SCHEMBL7085962 | 0.80 | KDM1A (0.48) | SMN1; SMN2ALDH1A1KDM1ACCR1CCR5 | |
| SCHEMBL25393432 | 0.79 | PLA2G7 (0.50) | SMN1; SMN2ALDH1A1KDM1APLA2G7CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 107 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10343998-B2 | Synthetic path to pharmaceutically acceptable Vismodegib | AZAD PHARMACEUTICAL INGREDIENTS AG (CH) | 2019-07-09 | — | — | US | claimed |
| EP-3381900-A1 | NEW SYNTHETIC PATH TO PHARMACEUTICALLY ACCEPTABLE VISMODEGIB | AZAD Pharmaceutical Ingredients AG (CH) | 2018-10-03 | — | — | EP | claimed |
| US-20180273477-A1 | Synthetic Path To Pharmaceutically Acceptable Vismodegib | AZAD PHARMACEUTICAL INGREDIENTS AG (CH) | 2018-09-27 | — | — | US | claimed |
| US-20240116872-A1 | PYRIDYL INHIBITORS FOR HEDGEHOG SIGNALLING | GENENTECH, INC. (US) | 2024-04-11 | — | — | US | disclosed |
| CN-117384087-A | Synthesis method of 2-chloro-N- [4-chloro-3- (2-pyridyl) phenyl ] -4- (methylsulfonyl) benzamide | 南京大学 | 2024-01-12 | — | — | CN | disclosed |
| US-20230265054-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GENENTECH, INC. (US) | 2023-08-24 | — | — | US | disclosed |
| US-20230265054-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GENENTECH, INC. (US) | 2023-08-24 | — | — | US | disclosed |
| US-20230265054-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GENENTECH, INC. (US) | 2023-08-24 | — | — | US | disclosed |
| WO-2023140809-A1 | NOVEL POLYMORPH OF VISMODEGIB AND METHOD OF PREPARATION | DEVA HOLDING (TR) | 2023-07-27 | — | — | WO | disclosed |
| WO-2022271109-A1 | NEW POLYMORPH OF VISMODEGIB AND METHOD FOR ITS PREPARATION | DEVA HOLDING (TR) | 2022-12-29 | — | — | WO | disclosed |
| CN-111056994-B | Preparation method of vismodegib | 新发药业有限公司 | 2021-08-17 | — | — | CN | disclosed |
| US-20090281089-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GENENTECH, INC. (US) | 2009-11-12 | — | — | US | disclosed |
| US-20090281089-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GENENTECH, INC. (US) | 2009-11-12 | — | — | US | disclosed |
| US-20090281089-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GENENTECH, INC. (US) | 2009-11-12 | — | — | US | disclosed |
| WO-2009126863-A2 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GENENTECH, INC. (US) | 2009-10-15 | — | — | WO | disclosed |
| WO-2009126863-A2 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GENENTECH, INC. (US) | 2009-10-15 | — | — | WO | disclosed |
| EP-1789390-A2 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | Genentech, Inc. (US) | 2007-05-30 | — | — | EP | disclosed |
| US-20060063779-A1 | Pyridyl inhibitors of hedgehog signalling | CURIS ROYALTY LLC | 2006-03-23 | — | — | US | disclosed |
| WO-2006028958-A2 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GENENTECH, INC. (US) | 2006-03-16 | — | — | WO | disclosed |
| WO-2006028958-A2 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GENENTECH, INC. (US) | 2006-03-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230265054-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | SHH, GLI1, SMO | SMN1; SMN2 4094/4885ALDH1A1 2407/4885SYK 2096/4885 |
| US-20240116872-A1 | PYRIDYL INHIBITORS FOR HEDGEHOG SIGNALLING | SHH, GLI1, SMO | SMN1; SMN2 4106/4885ALDH1A1 2371/4885SYK 2106/4885 |
| US-20090281089-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | SHH, GLI1, SMO | SMN1; SMN2 4094/4885ALDH1A1 2407/4885SYK 2096/4885 |
| US-10343998-B2 | Synthetic path to pharmaceutically acceptable Vismodegib | EGFR, SMO, ERBB2 | SMN1; SMN2 3496/4885ALDH1A1 2102/4885SYK 3313/4885 |
| US-20180273477-A1 | Synthetic Path To Pharmaceutically Acceptable Vismodegib | EGFR, SMO, ERBB2 | SMN1; SMN2 3496/4885ALDH1A1 2102/4885SYK 3313/4885 |
| US-20060063779-A1 | Pyridyl inhibitors of hedgehog signalling | SHH, GLI1, SMO | SMN1; SMN2 4094/4885ALDH1A1 2407/4885SYK 2096/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.