Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.67 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.57 |
| ▸ | USP30 | Q70CQ3 | 5/20 | 0.52 |
| ▸ | BTK | Q06187 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.51 |
| ▸ | CCR3 | P51677 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10168991 | 0.89 | HRH3 (0.53) | PKMNPC1MCHR1USP30HRH3 | |
| SCHEMBL10210766 | 0.86 | HRH3 (0.58) | USP30HRH3 | |
| SCHEMBL10168929 | 0.86 | USP30 (0.66) | PKMNPC1USP30HRH3RAB9A | |
| SCHEMBL10168938 | 0.86 | USP30 (0.52) | PKMNPC1USP30HRH3RAB9A | |
| SCHEMBL10210830 | 0.86 | PKM (0.72) | PKMNPC1MCHR1USP30BTK | |
| SCHEMBL10168959 | 0.84 | MCHR1 (0.52) | PKMNPC1MCHR1USP30HRH3 | |
| SCHEMBL10168946 | 0.84 | HRH3 (0.52) | NPC1MCHR1USP30HRH3RAB9A | |
| SCHEMBL10168947 | 0.83 | SMYD3 (0.55) | PKMNPC1USP30HRH3SMN1; SMN2 | |
| SCHEMBL13051465 | 0.82 | L3MBTL1 (0.64) | NPC1MCHR1RAB9A | |
| SCHEMBL10212614 | 0.82 | GRM5 (0.62) | USP30HRH3CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8586751-B2 | Nicotinamide compounds useful as kinase modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-11-19 | — | — | US | disclosed |
| US-20120082702-A1 | NICOTINAMIDE COMPOUNDS USEFUL AS KINASE MODULATORS | BRISTOL-MEYERS SQUIBB COMPANY | 2012-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120082702-A1 | NICOTINAMIDE COMPOUNDS USEFUL AS KINASE MODULATORS | NADK, BTK, NAMPT | PKM 981/4885NPC1 1778/4885MCHR1 4816/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.