Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.67 |
| ▸ | RAB9A | P51151 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.67 |
| ▸ | GFER | P55789 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.53 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.51 |
| ▸ | GRM5 | P41594 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.46 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10168947 | 0.85 | SMYD3 (0.55) | NPC1RAB9AKDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL10211684 | 0.85 | KDM4E (0.71) | NPC1RAB9AKDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL10212614 | 0.84 | GRM5 (0.62) | USP30GRM5HRH3MEN1KMT2A | |
| SCHEMBL13051465 | 0.84 | L3MBTL1 (0.64) | NPC1RAB9AMCHR1GRM5 | |
| SCHEMBL10210766 | 0.83 | HRH3 (0.58) | USP30HRH3 | |
| SCHEMBL10168946 | 0.83 | HRH3 (0.52) | NPC1RAB9AUSP30MCHR1HRH3 | |
| SCHEMBL10168929 | 0.83 | USP30 (0.66) | NPC1RAB9AUSP30GRM5HRH3 | |
| SCHEMBL10168938 | 0.83 | USP30 (0.52) | NPC1RAB9AUSP30GRM5HRH3 | |
| SCHEMBL10168991 | 0.82 | HRH3 (0.53) | NPC1RAB9AKDM4ESMN1; SMN2HTT | |
| SCHEMBL10169077 | 0.81 | HRH3 (0.48) | NPC1RAB9ASMN1; SMN2USP30HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8586751-B2 | Nicotinamide compounds useful as kinase modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-11-19 | — | — | US | disclosed |
| US-20120082702-A1 | NICOTINAMIDE COMPOUNDS USEFUL AS KINASE MODULATORS | BRISTOL-MEYERS SQUIBB COMPANY | 2012-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120082702-A1 | NICOTINAMIDE COMPOUNDS USEFUL AS KINASE MODULATORS | NADK, BTK, NAMPT | NPC1 1778/4885RAB9A 1841/4885KDM4E 2606/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.