Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.71 |
| ▸ | NPC1 | O15118 | 2/20 | 0.71 |
| ▸ | RAB9A | P51151 | 2/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.71 |
| ▸ | GFER | P55789 | 1/20 | 0.71 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.53 |
| ▸ | GRM5 | P41594 | 1/20 | 0.52 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.51 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10169095 | 0.85 | NPC1 (0.67) | KDM4ENPC1RAB9ASMN1; SMN2HSD17B10 | |
| SCHEMBL10211714 | 0.85 | HDAC4 (0.54) | KDM4ENPC1RAB9ASMN1; SMN2HSD17B10 | |
| SCHEMBL10212160 | 0.84 | NPC1 (0.69) | NPC1RAB9ASMN1; SMN2GRM5USP30 | |
| SCHEMBL10210732 | 0.84 | NPC1 (0.51) | KDM4ENPC1RAB9ASMN1; SMN2HSD17B10 | |
| SCHEMBL10211606 | 0.84 | SMYD3 (0.59) | KDM4ENPC1RAB9ASMN1; SMN2HSD17B10 | |
| SCHEMBL10212190 | 0.83 | L3MBTL1 (0.69) | NPC1RAB9AMCHR1GRM5 | |
| SCHEMBL10210847 | 0.82 | CTSL (0.57) | USP30CHEK1HDAC4HDAC6 | |
| SCHEMBL4356360 | 0.82 | CTSL (0.57) | USP30CHEK1HDAC4HDAC6 | |
| SCHEMBL10210729 | 0.82 | USP30 (0.70) | NPC1RAB9AKDM2BUSP30CHEK1 | |
| SCHEMBL10210733 | 0.82 | ALDH1A1 (0.51) | NPC1RAB9AUSP30CHEK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120082702-A1 | NICOTINAMIDE COMPOUNDS USEFUL AS KINASE MODULATORS | BRISTOL-MEYERS SQUIBB COMPANY | 2012-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120082702-A1 | NICOTINAMIDE COMPOUNDS USEFUL AS KINASE MODULATORS | NADK, BTK, NAMPT | KDM4E 2606/4885NPC1 1778/4885RAB9A 1841/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.