Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 3/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.39 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11917500 | 0.92 | SRC (0.53) | SRCMCHR1JAK2JAK1TYK2 | |
| SCHEMBL11917505 | 0.91 | ALDH1A1 (0.50) | SRCMCHR1JAK2JAK1TYK2 | |
| SCHEMBL12782522 | 0.90 | SMN1; SMN2 (0.44) | SRCMCHR1JAK2JAK1TYK2 | |
| SCHEMBL254389 | 0.83 | SRC (0.54) | SRCMCHR1CHRM3HTTNPC1 | |
| SCHEMBL254561 | 0.82 | ALDH1A1 (0.54) | SRCMCHR1CHRM3HTTNPC1 | |
| SCHEMBL12782469 | 0.81 | LMNA (0.47) | SRCMCHR1JAK2JAK1TYK2 | |
| SCHEMBL16572268 | 0.80 | SRC (0.56) | SRCMCHR1HTTNPC1RAB9A | |
| SCHEMBL11917498 | 0.79 | SRC (0.66) | SRCEPHX2ABL1TUBB4ATUBB | |
| SCHEMBL13096530 | 0.79 | CHRM4 (0.43) | MCHR1NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL254626 | 0.79 | SRC (0.56) | SRCMCHR1JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836169-B9 | COMPOSITIONS AND METHODS OF TREATING CELL PROLIFERATION DISORDERS | KINEX PHARMACEUTICALS LLC (US) | 2012-07-04 | — | — | EP | disclosed |
| EP-1836169-B1 | COMPOSITIONS AND METHODS OF TREATING CELL PROLIFERATION DISORDERS | KINEX PHARMACEUTICALS LLC (US) | 2012-02-08 | — | — | EP | disclosed |