Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 9/20 | 0.53 |
| ▸ | SRC | P12931 | 2/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.52 |
| ▸ | NAMPT | P43490 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | PRKACA | P17612 | 2/20 | 0.48 |
| ▸ | GSK3A | P49840 | 2/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | PRKX | P51817 | 2/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.48 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | PRKCG | P05129 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL254175 | 0.87 | SRC (0.69) | ROCK2SRCROCK1NAMPTTP53 | |
| SCHEMBL254400 | 0.85 | ROCK2 (0.62) | ROCK2SRCROCK1NAMPTTP53 | |
| SCHEMBL3030331 | 0.85 | HDAC6 (0.63) | ROCK2SRCROCK1NAMPTTP53 | |
| SCHEMBL3462286 | 0.81 | HDAC2 (0.60) | SRCNAMPTTP53MAPT | |
| SCHEMBL20804355 | 0.80 | HPGD (0.57) | ROCK2SRCNAMPTTP53MAPT | |
| SCHEMBL25718877 | 0.80 | ROCK2 (0.74) | ROCK2ROCK1PRKACAGSK3AGSK3B | |
| SCHEMBL10194841 | 0.80 | MMP13 (0.61) | ROCK2NAMPTTP53MAPT | |
| SCHEMBL14082551 | 0.79 | ROCK2 (0.59) | ROCK2SRCROCK1MAPTPRKACA | |
| SCHEMBL5338226 | 0.79 | HPGD (0.63) | ROCK2NAMPTTP53MAPT | |
| SCHEMBL14082865 | 0.79 | MAPK1 (0.57) | ROCK2SRCROCK1NAMPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836169-B9 | COMPOSITIONS AND METHODS OF TREATING CELL PROLIFERATION DISORDERS | KINEX PHARMACEUTICALS LLC (US) | 2012-07-04 | — | — | EP | disclosed |
| EP-1836169-B1 | COMPOSITIONS AND METHODS OF TREATING CELL PROLIFERATION DISORDERS | KINEX PHARMACEUTICALS LLC (US) | 2012-02-08 | — | — | EP | disclosed |