Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 10/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | NCF1 | P14598 | 1/20 | 0.34 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL408981 | 0.99 | AURKA (0.42) | AURKADHODHHDAC6TAS2R14ERBB2 | |
| SCHEMBL18117609 | 0.93 | AURKA (0.39) | AURKADHODHHDAC6TAS2R14ERBB2 | |
| SCHEMBL10171579 | 0.81 | AURKA (0.50) | AURKATAS2R14PTK6AURKB | |
| Hydrochloric Acid SCHEMBL404425 | 0.80 | AURKA (0.49) | AURKATAS2R14PTK6AURKB | |
| SCHEMBL407572 | 0.78 | PTK6 (0.59) | AURKAPTK6 | |
| Hydrochloric Acid SCHEMBL409150 | 0.78 | PTK6 (0.58) | AURKAPTK6 | |
| SCHEMBL405037 | 0.78 | TAAR1 (0.44) | AURKAERBB2PTK6TAAR1 | |
| SCHEMBL10172210 | 0.77 | AURKA (0.43) | AURKAERBB2PTK6AURKB | |
| Hydrochloric Acid SCHEMBL409054 | 0.76 | AURKA (0.43) | AURKAERBB2PTK6TAAR1 | |
| SCHEMBL407996 | 0.76 | AURKA (0.58) | AURKAERBB2PTK6AURKBTAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367822-B1 | TRICYCLIC AZAINDOLES | MERCK PATENT GMBH (DE) | 2016-10-05 | — | — | EP | claimed |
| US-8853391-B2 | Tricyclic azaindoles | MERCK PATENT GMBH (DE) | 2014-10-07 | — | — | US | disclosed |
| US-20120022060-A1 | Tricyclic Azaindoles | MERCK PATENT GMBH (DE) | 2012-01-26 | — | — | US | disclosed |
| WO-2010080253-A1 | TRICYCLIC AZAINDOLES | MERCK PATENT GMBH (DE) | 2010-07-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120022060-A1 | Tricyclic Azaindoles | AZI2, DCK, PPP2CA | AURKA 515/4885DHODH 1676/4885HDAC6 621/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.