PPP2CA

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform · P67775 · PPP2CA on Sugi Atlas →

498 patent compounds predicted against PPP2CA, 390 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL817509 SCHEMBL817509 1.00 7/20
SCHEMBL15381932 SCHEMBL15381932 1.00 7/20
SCHEMBL15381934 SCHEMBL15381934 1.00 7/20
SCHEMBL15381935 SCHEMBL15381935 1.00 7/20
SCHEMBL15382081 SCHEMBL15382081 1.00 7/20
SCHEMBL15445017 SCHEMBL15445017 1.00 7/20
SCHEMBL15445018 SCHEMBL15445018 1.00 7/20
SCHEMBL15445020 SCHEMBL15445020 1.00 7/20
SCHEMBL15381941 SCHEMBL15381941 0.90 7/20
SCHEMBL15444942 SCHEMBL15444942 0.90 7/20
SCHEMBL15381939 SCHEMBL15381939 0.90 7/20
SCHEMBL15381940 SCHEMBL15381940 0.90 7/20
SCHEMBL15444944 SCHEMBL15444944 0.90 7/20
SCHEMBL15444945 SCHEMBL15444945 0.90 7/20
SCHEMBL15381938 SCHEMBL15381938 0.90 7/20
SCHEMBL889296 SCHEMBL889296 0.89 7/20
SCHEMBL889307 SCHEMBL889307 0.89 7/20
SCHEMBL15381933 SCHEMBL15381933 0.88 7/20
SCHEMBL15381936 SCHEMBL15381936 0.86 7/20
SCHEMBL15444943 SCHEMBL15444943 0.86 7/20

Clinical trials — most relevant to PPP2CA by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Rectal Tacrolimus in the Treatment of Resistant Ulcerative Proctitis PHASE4COMPLETED
Lithium for Prevention of Cognitive Declining in Mood Illnesses PHASE4NOT_YET_RECRUITING
The G Protein-Coupled Receptor Kinase Type 2 Inhibitor Paroxetine as Adjunctive Therapy to Improve Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus PHASE3UNKNOWN
Efficacy and Safety of Endoxifen in Bipolar I Disorder Patients PHASE3ACTIVE_NOT_RECRUITING
Efficacy and Safety of 0.25% Timolol Gel in Healing Surgical Open Wounds PHASE2/PHASE3COMPLETED
Evaluate Efficacy and Safety of Endoxifen in Bipolar I Disorder Patients PHASE3COMPLETED
Study Evaluating Toxicity & Efficacy of Lenalidomide(Revlimid®)in Chemotherapy-Naïve AIPC Patients PHASE2COMPLETED
Acetylcarnitine and Insulin Sensitivity PHASE2COMPLETED
The Phosphodiesterase 4 Inhibitor Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients PHASE1/PHASE2WITHDRAWN
Clinical Study of EBV-LMP1 Targeted DNAzyme to Treat Nasopharyngeal Carcinoma PHASE1/PHASE2COMPLETED
Pentoxifylline as an Adjunctive in Treatment of Negative Symptoms in Chronic Schizophrenia PHASE1/PHASE2COMPLETED
Evaluating MED2005 & Nitrostat Bioavailability PHASE1COMPLETED
Phase I Dose Finding and Proof-of-concept Study of Panobinostat With Standard Dose Cytarabine and Daunorubicin for Untreated Acute Myeloid Leukemia or Advanced Myelodysplastic Syndrome PHASE1COMPLETED
Bioequivalence Study of Tacrolimus in Healthy Volunteers PHASE1COMPLETED
5-aza-4'-Thio-2'-Deoxycytidine (Aza-TdC) in People With Advanced Solid Tumors PHASE1RECRUITING
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma PHASE1COMPLETED
Impact of Nrf2 Activation on Macrovascular, Microvascular & Leg Function & Walking Capacity in Peripheral Artery Disease EARLY_PHASE1RECRUITING
Quantification of GADD34 Expression in RA nanCOMPLETED
Duality of Lipids: the Athlete's Paradox nanCOMPLETED
Effect of Esterogen Receptor Modulator on Gene in Bipolar Diseas nanNOT_YET_RECRUITING
Immune Signature of Palmoplantar Pustulosis nanCOMPLETED
IVF Outcome in Polycystic Ovary Syndrome Patients nanUNKNOWN
The Phosphodiesterase-3 Inhibitor Cilostazol as an Adjunctive to Antidepressants in Patients With Major Depressive Disorder. nanCOMPLETED
Vulvodynia: Identification of Potential Relevant Biomarkers nanCOMPLETED
The Effect Of DAAs on miRNA-122 And Insulin Resistance In Chronic HCV Patients nanUNKNOWN
Ischemic Preconditioning to Prevent Acute Kidney Injury nanCOMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
99Tc-MDP in Postmenopausal Women With Differentiated Thyroid Cancer and Osteoporosis nanCOMPLETED
The Study of HIV Protease Inhibitors and Their Effects on Glucose Metabolism nanCOMPLETED
Ischemic Preconditioning - Perspectives of Use Vivio/in Vitro Studies nanENROLLING_BY_INVITATION

Related proteins — ESM-2 sequence neighbours (a PPP2CA binder may also engage these)

ProteinNameSimilarity
P63330 1.000 P63330 →
P48463 1.000 P48463 →
P23696 1.000 P23696 →
Q10BT5 1.000 Q10BT5 →
Q9XGH7 1.000 Q9XGH7 →
Q0E2S4 1.000 Q0E2S4 →
P62715 1.000 P62715 →
P48578 1.000 P48578 →
Q0P594 1.000 Q0P594 →
A3C4N5 1.000 A3C4N5 →
A9JRC7 1.000 A9JRC7 →
Q9XZE5 1.000 Q9XZE5 →
P48579 1.000 P48579 →
Q07098 1.000 Q07098 →
P67774 1.000 P67774 →
A2XN40 1.000 A2XN40 →
Q8X178 1.000 Q8X178 →
P63331 1.000 P63331 →
P67777 1.000 P67777 →
P67776 1.000 P67776 →
Q06009 1.000 Q06009 →
P32345 1.000 P32345 →
Q07099 1.000 Q07099 →
Q6IP91 1.000 Q6IP91 →
P11611 1.000 P11611 →
P62716 1.000 P62716 →
Q6P861 1.000 Q6P861 →
P62714 1.000 P62714 →
PPP6C Serine/threonine-protein phosphatase 6 catalytic subunit 1.000 landscape →
P23635 0.999 P23635 →