Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 12/20 | 0.55 |
| ▸ | CYP11B1 | P15538 | 10/20 | 0.55 |
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.44 |
| ▸ | PDE2A | O00408 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10175114 | 0.85 | CYP11B2 (0.45) | CYP11B2CYP11B1POLBSMN1; SMN2 | |
| SCHEMBL10175104 | 0.85 | CYP11B2 (0.45) | CYP11B2CYP11B1POLBSMN1; SMN2 | |
| SCHEMBL17897061 | 0.85 | CYP11B2 (0.45) | CYP11B2CYP11B1PDE10APDE2APOLB | |
| SCHEMBL17883782 | 0.84 | CYP11B2 (0.48) | CYP11B2CYP11B1PDE10APOLBSMN1; SMN2 | |
| SCHEMBL17896610 | 0.81 | CYP11B2 (0.53) | CYP11B2CYP11B1PDE10APOLBSMN1; SMN2 | |
| SCHEMBL17897060 | 0.81 | MEN1 (0.57) | CYP11B2CYP11B1 | |
| SCHEMBL432104 | 0.80 | PDE10A (0.65) | CYP11B2CYP11B1PDE10APDE2APOLB | |
| SCHEMBL10175358 | 0.80 | PDE10A (0.65) | CYP11B2CYP11B1PDE10APDE2APOLB | |
| SCHEMBL17896729 | 0.80 | PDE10A (0.46) | CYP11B2CYP11B1PDE10APDE2APOLB | |
| SCHEMBL461090 | 0.80 | CYP11B2 (0.67) | CYP11B2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| WO-2012012478-A1 | ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-26 | — | — | WO | disclosed |