Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 13/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 11/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.39 |
| ▸ | PRKACA | P17612 | 2/20 | 0.39 |
| ▸ | LTK | P29376 | 2/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.39 |
| ▸ | CDK8 | P49336 | 2/20 | 0.39 |
| ▸ | CLK2 | P49760 | 2/20 | 0.39 |
| ▸ | CDK9 | P50750 | 2/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10175114 | 0.85 | CYP11B2 (0.45) | CYP11B2CYP11B1POLBSMN1; SMN2DAPK3 | |
| SCHEMBL17897061 | 0.85 | CYP11B2 (0.45) | CYP11B2CYP11B1POLBSMN1; SMN2DAPK3 | |
| SCHEMBL10175109 | 0.85 | CYP11B2 (0.55) | CYP11B2CYP11B1POLBSMN1; SMN2 | |
| SCHEMBL17883782 | 0.82 | CYP11B2 (0.48) | CYP11B2CYP11B1POLBSMN1; SMN2 | |
| SCHEMBL17896616 | 0.81 | CYP11B2 (0.43) | CYP11B2CYP11B1DAPK3MAP4K4PRKACA | |
| SCHEMBL17896608 | 0.81 | CYP11B2 (0.66) | CYP11B2CYP11B1 | |
| SCHEMBL17896693 | 0.81 | PDE10A (0.50) | CYP11B2CYP11B1POLBSMN1; SMN2GSK3B | |
| SCHEMBL17883794 | 0.81 | CYP11B2 (0.40) | CYP11B2CYP11B1DAPK3MAP4K4PRKACA | |
| SCHEMBL17897060 | 0.79 | MEN1 (0.57) | CYP11B2CYP11B1DAPK3MAP4K4PRKACA | |
| SCHEMBL31339766 | 0.78 | MEN1 (0.59) | CYP11B2CYP11B1POLBSMN1; SMN2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| WO-2012012478-A1 | ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-26 | — | — | WO | disclosed |