Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.64 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.58 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.58 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.54 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.49 |
| ▸ | KIT | P10721 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | BCR | P11274 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17896670 | 0.87 | NAMPT (0.67) | NAMPTCYP11B1CYP11B2HDAC1HDAC8 | |
| SCHEMBL10175457 | 0.86 | NAMPT (0.70) | NAMPTCYP11B1CYP11B2HDAC1HDAC8 | |
| SCHEMBL17896668 | 0.84 | NAMPT (0.61) | NAMPTCYP11B1CYP11B2HDAC1HDAC8 | |
| SCHEMBL17896675 | 0.84 | CYP11B2 (0.63) | CYP11B1CYP11B2CYP19A1SLC2A1 | |
| SCHEMBL17896669 | 0.83 | HDAC1 (0.50) | NAMPTCYP11B1CYP11B2CYP19A1HDAC1 | |
| SCHEMBL19763370 | 0.82 | HDAC6 (0.59) | NAMPTHDAC1HDAC8HDAC6HDAC3 | |
| SCHEMBL10175817 | 0.79 | RAD51 (0.60) | NAMPTCYP11B1CYP11B2CYP19A1KDM4E | |
| SCHEMBL10175103 | 0.79 | NAMPT (0.61) | NAMPTCYP11B1CYP11B2KITALDH1A1 | |
| SCHEMBL7812395 | 0.78 | CYP11B2 (0.58) | NAMPTCYP11B1CYP11B2CYP19A1SLC2A1 | |
| SCHEMBL30158985 | 0.78 | NPC1 (0.61) | NAMPTHDAC1HDAC8HDAC6HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012012478-A1 | ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-26 | — | — | WO | disclosed |