Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.52 |
| ▸ | KIT | P10721 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | BCR | P11274 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31720959 | 0.82 | NAMPT (0.59) | NAMPTALDH1A1HSD17B10NPC1ABL1 | |
| SCHEMBL26603148 | 0.82 | NAMPT (0.59) | NAMPTALDH1A1HSD17B10NPC1ABL1 | |
| SCHEMBL460529 | 0.81 | NAMPT (0.53) | NAMPTALDH1A1CYP11B1CYP11B2KIT | |
| SCHEMBL17896670 | 0.80 | NAMPT (0.67) | NAMPTALDH1A1HSD17B10CYP11B1CYP11B2 | |
| SCHEMBL10175457 | 0.79 | NAMPT (0.70) | NAMPTALDH1A1HSD17B10CYP11B1CYP11B2 | |
| SCHEMBL10175112 | 0.79 | NAMPT (0.64) | NAMPTALDH1A1CYP11B1CYP11B2KIT | |
| SCHEMBL17896668 | 0.77 | NAMPT (0.61) | NAMPTALDH1A1CYP11B1CYP11B2KIT | |
| SCHEMBL10175606 | 0.76 | CYP11B2 (0.60) | NAMPTALDH1A1CYP11B1CYP11B2KIT | |
| SCHEMBL10176218 | 0.76 | CYP11B2 (0.60) | NAMPTALDH1A1HPGDHSD17B10CYP11B1 | |
| SCHEMBL10176167 | 0.76 | CYP11B2 (0.80) | NAMPTCYP11B1CYP11B2KITATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| WO-2012012478-A1 | ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-26 | — | — | WO | disclosed |