Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | RHEB | Q15382 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17896659 | 0.88 | MEN1 (0.59) | MEN1KMT2ACYP11B1CYP11B2ATM | |
| SCHEMBL17896740 | 0.84 | CYP11B2 (0.67) | CYP11B1CYP11B2ATMHTTKIT | |
| SCHEMBL17896741 | 0.82 | CYP11B2 (0.47) | CYP11B1CYP11B2ATMALOX15HTT | |
| SCHEMBL17896744 | 0.82 | CYP11B2 (0.47) | CYP11B1CYP11B2ATMALOX15HTT | |
| SCHEMBL17896640 | 0.81 | CYP11B2 (0.66) | MEN1KMT2ACYP11B1CYP11B2ALOX15 | |
| SCHEMBL10175347 | 0.79 | CYP11B2 (0.74) | CYP11B1CYP11B2 | |
| SCHEMBL10249413 | 0.79 | MEN1 (0.63) | MEN1KMT2ACYP11B1CYP11B2ATM | |
| SCHEMBL17896717 | 0.78 | MEN1 (0.62) | MEN1KMT2ACYP11B1CYP11B2ATM | |
| SCHEMBL10175359 | 0.78 | MEN1 (0.62) | MEN1KMT2ACYP11B1CYP11B2ATM | |
| SCHEMBL432410 | 0.77 | CYP11B2 (0.56) | CYP11B1CYP11B2ATMALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| WO-2012012478-A1 | ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-26 | — | — | WO | disclosed |