Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | MERTK | Q12866 | 1/20 | 0.41 |
| ▸ | TDP2 | O95551 | 2/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12944870 | 0.81 | MAPT (0.47) | SMN1; SMN2LMNAHTR7HTR1ACYP1A2 | |
| SCHEMBL12362814 | 0.78 | HTR7 (0.51) | SMN1; SMN2HTR7HTR1AMAPTPRMT5 | |
| SCHEMBL20320421 | 0.77 | MAPT (0.67) | SMN1; SMN2LMNAHTTHTR7HTR1A | |
| SCHEMBL10145036 | 0.75 | HTR7 (0.43) | SMN1; SMN2HTR7HTR1AMAPTPRMT5 | |
| SCHEMBL14996675 | 0.75 | SMN1; SMN2 (0.44) | SMN1; SMN2LMNAHTTCYP1A2MAPT | |
| SCHEMBL10176300 | 0.75 | HTR7 (0.43) | SMN1; SMN2LMNAHTR7HTR1ACYP1A2 | |
| SCHEMBL19368997 | 0.72 | HTR7 (0.41) | HTR7HTR1ACYP1A2MAPTPRMT5 | |
| SCHEMBL31617583 | 0.72 | SMN1; SMN2 (0.42) | SMN1; SMN2LMNAHTTCYP1A2MAPT | |
| SCHEMBL2828496 | 0.69 | HTR7 (0.67) | HTR7HTR1AMAPTPRMT5WDR77 | |
| SCHEMBL4021817 | 0.69 | MAPT (0.44) | HTR7HTR1AMAPTPRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120115869-A1 | TETRAZOLE DERIVATIVES | MERCK SERONO S.A. (CH) | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120115869-A1 | TETRAZOLE DERIVATIVES | TSLP, IL5, CMA1 | SMN1; SMN2 3831/4885LMNA 4204/4885HTT 2807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.