Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPBWR1 | P48145 | 10/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 9/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29624191 | 0.83 | KDM4E (0.73) | KDM4ESMN1; SMN2KMT2AALDH1A1MEN1 | |
| SCHEMBL7701732 | 0.83 | KDM4E (0.73) | KDM4ESMN1; SMN2KMT2AALDH1A1MEN1 | |
| SCHEMBL27254297 | 0.82 | KDM4E (0.59) | KDM4ESMN1; SMN2KMT2AALDH1A1MEN1 | |
| SCHEMBL22560252 | 0.82 | KDM4E (0.54) | KDM4ESMN1; SMN2KMT2AALDH1A1MEN1 | |
| SCHEMBL4201391 | 0.80 | KDM4E (1.00) | KDM4ESMN1; SMN2KMT2AALDH1A1MEN1 | |
| SCHEMBL10360896 | 0.79 | NPC1 (0.42) | KDM4ESMN1; SMN2KMT2AALDH1A1MEN1 | |
| SCHEMBL30117642 | 0.74 | KDM4E (0.75) | KDM4EKMT2AALDH1A1MEN1NPC1 | |
| SCHEMBL9980902 | 0.74 | KDM4E (0.63) | KDM4ESMN1; SMN2KMT2AMEN1NPC1 | |
| SCHEMBL5324211 | 0.72 | SMN1; SMN2 (0.71) | KDM4ESMN1; SMN2KMT2AALDH1A1MEN1 | |
| SCHEMBL10590745 | 0.71 | KDM4E (0.55) | KDM4ESMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9067928-B2 | Compounds and methods of use | ABBVIE INC. (US) | 2015-06-30 | — | — | US | disclosed |
| US-8518970-B2 | Compounds and methods of use | ABBVIE INC. (US) | 2013-08-27 | — | — | US | disclosed |
| US-20120184541-A1 | COMPOUNDS AND METHODS OF USE | ABBVIE INC. | 2012-07-19 | — | — | US | disclosed |
| US-8114893-B2 | Compounds and methods of use | GENENTECH, INC. (US) | 2012-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120184541-A1 | COMPOUNDS AND METHODS OF USE | BCL2A1, BCL2, BAX | KDM4E 2909/4885SMN1; SMN2 1830/4885KMT2A 2710/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.