Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.73 |
| ▸ | NPC1 | O15118 | 8/20 | 0.53 |
| ▸ | RAB9A | P51151 | 8/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | HPGD | P15428 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4201391 | 0.84 | KDM4E (1.00) | KDM4ESMN1; SMN2LMNAMAPTHPGD | |
| SCHEMBL7701732 | 0.83 | KDM4E (0.73) | KDM4ENPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL10176225 | 0.83 | KDM4E (0.67) | KDM4ENPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL30117642 | 0.78 | KDM4E (0.75) | KDM4ENPC1RAB9ALMNAMAPT | |
| SCHEMBL9980902 | 0.77 | KDM4E (0.63) | KDM4ENPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL10447432 | 0.77 | RAB9A (0.49) | KDM4ENPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL19100208 | 0.74 | KDM4E (0.55) | KDM4EALDH1A1PKM | |
| Fumaric Acid SCHEMBL10590166 | 0.74 | KDM4E (0.77) | KDM4ENPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL27254297 | 0.74 | KDM4E (0.59) | KDM4ENPC1RAB9ASMN1; SMN2LMNA | |
| Maleic Acid SCHEMBL10590159 | 0.74 | KDM4E (0.77) | KDM4ENPC1RAB9ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4003991-A1 | HETEROARYL-SUBSTITUTED PYRAZOLO-PYRIDINE PROTEIN KINASE INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH | HepaRegeniX GmbH (DE) | 2022-06-01 | — | — | EP | disclosed |