Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.49 |
| ▸ | DPP4 | P27487 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | PI4KA | P42356 | 1/20 | 0.46 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.46 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.46 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.46 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL10590166 | 0.88 | KDM4E (0.77) | KDM4EHIF1ADPP4ALDH1A1MEN1 | |
| Maleic Acid SCHEMBL10590159 | 0.88 | KDM4E (0.77) | KDM4EHIF1ADPP4ALDH1A1MEN1 | |
| SCHEMBL30117642 | 0.86 | KDM4E (0.75) | KDM4EALDH1A1HSD17B10CYP1A2MEN1 | |
| SCHEMBL7701732 | 0.84 | KDM4E (0.73) | KDM4EHIF1AALDH1A1HSD17B10CYP1A2 | |
| SCHEMBL29624191 | 0.84 | KDM4E (0.73) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL10176225 | 0.80 | KDM4E (0.67) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL29714856 | 0.80 | KDM4E (0.67) | KDM4EDPP4ALDH1A1CYP1A2CYP17A1 | |
| SCHEMBL5683198 | 0.80 | KDM4E (0.67) | KDM4EDPP4ALDH1A1CYP1A2CYP17A1 | |
| SCHEMBL9980902 | 0.78 | KDM4E (0.63) | KDM4EMEN1KMT2AHTTMAPT | |
| SCHEMBL29624329 | 0.77 | KDM4E (0.62) | KDM4EHIF1AALDH1A1CYP17A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119285629-A | 5- [1,2, 4-Oxadiazole ] -6-oxygen-pyrazolopyridine derivative and preparation method and application thereof | 中南大学 | 2025-01-10 | — | — | CN | claimed |
| CN-119285629-A | 5- [1,2, 4-Oxadiazole ] -6-oxygen-pyrazolopyridine derivative and preparation method and application thereof | 中南大学 | 2025-01-10 | — | — | CN | disclosed |
| US-9796711-B2 | Substituted pyrazolo[3,4-b]pyridin-6-carboxylic acids and method of use | ABBVIE S.Á.R.L. (LU) | 2017-10-24 | — | — | US | disclosed |
| US-8536194-B2 | Pyrazolopyridine derivates | PALAU PHARMA, S.A. (ES) | 2013-09-17 | — | — | US | disclosed |
| US-20090286983-A1 | Pyrazolopyridine Derivates | PALAU PHARMA, S.A. (ES) | 2009-11-19 | — | — | US | disclosed |
| US-20090005377-A1 | Pyrazolopyridine Derivates | PALAU PHARMA, S.A. (ES) | 2009-01-01 | — | — | US | disclosed |
| US-7468376-B2 | Pyrazolopyridine derivates | PALAU PHARMA, S.A. (ES) | 2008-12-23 | — | — | US | disclosed |
| US-20070148185-A1 | Novel therapeutic target for protozoal diseases | VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY | 2007-06-28 | — | — | US | disclosed |
| US-20060167040-A1 | Pyrazolopyridine derivates | J. URIACH Y COMPANIA S.A. (ES) | 2006-07-27 | — | — | US | disclosed |
| EP-0338087-A1 | FUSED PYRAZOLE COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND THEIR MEDICINAL USE | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1989-10-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060167040-A1 | Pyrazolopyridine derivates | MAPK1, MAP4K2, MAP4K3 | KDM4E 3384/4885HIF1A 3778/4885DPP4 1311/4885 |
| US-20090286983-A1 | Pyrazolopyridine Derivates | MAPK1, MAPK4, MAP4K2 | KDM4E 3953/4885HIF1A 3856/4885DPP4 1956/4885 |
| US-20090005377-A1 | Pyrazolopyridine Derivates | MAPK1, MAPK4, MAP4K2 | KDM4E 3953/4885HIF1A 3856/4885DPP4 1956/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.