SCHEMBL10180669

SCHEMBL10180669

O=C(Oc1cccc(F)c1F)c1ccccc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.58
MAPT P10636 3/20 0.58
SMN1; SMN2 Q16637 2/20 0.58
HSD17B10 Q99714 2/20 0.54
ESR1 P03372 2/20 0.54
ESR2 Q92731 2/20 0.54
MEN1 O00255 1/20 0.54
JAK2 O60674 1/20 0.54
USP2 O75604 1/20 0.54
GAA P10253 1/20 0.54
ALOX15 P16050 1/20 0.54
NPSR1 Q6W5P4 1/20 0.54
SLC2A1 P11166 1/20 0.53
SLC2A4 P14672 1/20 0.53
SLC6A3 Q01959 1/20 0.51
LMNA P02545 2/20 0.50
METAP2 P50579 1/20 0.50
METAP1 P53582 1/20 0.50
HDAC6 Q9UBN7 1/20 0.50
TOP1 P11387 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10179781 0.87 KMT2A (0.55) KMT2AMAPTSMN1; SMN2HSD17B10ESR1
SCHEMBL1323923 0.87 KMT2A (0.63) KMT2AMAPTSMN1; SMN2HSD17B10ESR1
SCHEMBL10091220 0.85 ESR1 (0.57) KMT2AMAPTSMN1; SMN2ESR1ESR2
SCHEMBL2886267 0.84 SLC2A1 (0.72) KMT2AMAPTSMN1; SMN2HSD17B10ESR1
SCHEMBL27738180 0.83 KMT2A (0.54) KMT2AMAPTSMN1; SMN2HSD17B10ESR1
SCHEMBL27554704 0.81 SERPINE1 (0.70) KMT2AMAPTSMN1; SMN2HSD17B10ESR1
SCHEMBL13378038 0.81 ESR1 (0.54) KMT2AMAPTSMN1; SMN2ESR1ESR2
SCHEMBL725404 0.80 KMT2A (0.76) KMT2AMAPTSMN1; SMN2HSD17B10ESR1
SCHEMBL10180647 0.79 SLC2A1 (0.57) KMT2AMAPTSMN1; SMN2HSD17B10ESR1
SCHEMBL10180340 0.79 KMT2A (0.50) KMT2AMAPTSMN1; SMN2HSD17B10ESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110938439-A High-polarity large-optical birefringence liquid crystal composition 清华大学 2020-03-31 CN disclosed
US-9624159-B2 Aniline derivatives, their preparation and their therapeutic application SANOFI (FR) 2017-04-18 US disclosed
US-9249085-B2 Aniline derivatives, their preparation and their therapeutic application FOVEA PHARMACEUTICALS (FR) 2016-02-02 US disclosed
CN-104112870-A Nonaqueous electrolyte solution and nonaqueous electrolyte battery using same MITSUBISHI CHEM CORP 2014-10-22 CN disclosed
US-20130244122-A1 NONAQUEOUS ELECTROLYTIC SOLUTION AND NONAQUEOUS-ELECTROLYTE BATTERY EMPLOYING THE SAME ONUKI MASAMICHI (JP) 2013-09-19 US disclosed
US-20120219866-A1 NONAQUEOUS ELECTROLYTIC SOLUTION AND NONAQUEOUS-ELECTROLYTE BATTERY EMPLOYING THE SAME MITSUBISHI CHEMICAL CORPORATION (JP) 2012-08-30 US disclosed
EP-2475041-A1 NON-AQUEOUS ELECTROLYTIC SOLUTION, AND NON-AQUEOUS ELECTROLYTE BATTERY COMPRISING SAME Mitsubishi Chemical Corporation (JP) 2012-07-11 EP disclosed
CN-102484281-A Nonaqueous electrolyte solution and nonaqueous electrolyte battery using same MITSUBISHI CHEM CORP 2012-05-30 CN disclosed