Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 7/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 4/20 | 0.42 |
| ▸ | BRAF | P15056 | 4/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10180610 | 0.92 | TRPV4 (0.49) | TRPV4LMNATHRBKMT2ASMN1; SMN2 | |
| SCHEMBL10181159 | 0.89 | TRPV4 (0.45) | TRPV4LMNATHRBKMT2AMEN1 | |
| SCHEMBL10181136 | 0.87 | MAPK8 (0.47) | TRPV4LMNATHRBKMT2ASMN1; SMN2 | |
| SCHEMBL10180941 | 0.86 | TRPV4 (0.42) | TRPV4LMNATHRBKMT2ASMN1; SMN2 | |
| SCHEMBL964841 | 0.84 | KMT2A (0.49) | LMNATHRBKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL1010086 | 0.83 | KMT2A (0.48) | LMNATHRBKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL964139 | 0.83 | KMT2A (0.48) | TRPV4LMNATHRBKMT2ASMN1; SMN2 | |
| SCHEMBL967745 | 0.83 | KMT2A (0.47) | TRPV4LMNATHRBKMT2ASMN1; SMN2 | |
| SCHEMBL1012121 | 0.82 | KMT2A (0.45) | TRPV4LMNATHRBKMT2ASMN1; SMN2 | |
| SCHEMBL10180611 | 0.80 | TRPV4 (0.46) | TRPV4LMNATHRBKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | disclosed |