Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 11/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10181136 | 0.93 | MAPK8 (0.47) | TRPV4THRBEPHX2ARLMNA | |
| SCHEMBL10180940 | 0.89 | TRPV4 (0.45) | TRPV4THRBEPHX2ARLMNA | |
| SCHEMBL10181160 | 0.86 | TRPV4 (0.42) | TRPV4THRBEPHX2ARLMNA | |
| SCHEMBL10182155 | 0.85 | TRPV4 (0.48) | TRPV4THRBEPHX2KMT2AMEN1 | |
| SCHEMBL966376 | 0.84 | MAPT (0.42) | LMNAKMT2AMEN1RAF1 | |
| SCHEMBL10180610 | 0.82 | TRPV4 (0.49) | TRPV4THRBEPHX2LMNAKMT2A | |
| SCHEMBL12946857 | 0.80 | TRPV4 (0.44) | TRPV4THRBEPHX2LMNAKMT2A | |
| SCHEMBL964428 | 0.79 | SMN1; SMN2 (0.42) | KMT2AMEN1 | |
| SCHEMBL10180583 | 0.79 | TRPV4 (0.42) | TRPV4THRBEPHX2LMNAKMT2A | |
| SCHEMBL10181137 | 0.79 | MAPK8 (0.45) | TRPV4THRBEPHX2LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | disclosed |