Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.36 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | PI4KA | P42356 | 1/20 | 0.33 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.33 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26111611 | 0.98 | KCNH2 (0.39) | KCNH2GPR84HCAR2HCAR3CYP3A4 | |
| SCHEMBL11444203 | 0.98 | KCNH2 (0.39) | KCNH2GPR84HCAR2HCAR3CYP3A4 | |
| SCHEMBL26112848 | 0.98 | KCNH2 (0.39) | KCNH2GPR84HCAR2HCAR3CYP3A4 | |
| SCHEMBL27724995 | 0.98 | KCNH2 (0.39) | KCNH2GPR84HCAR2HCAR3CYP3A4 | |
| SCHEMBL21634151 | 0.98 | KCNH2 (0.39) | KCNH2GPR84HCAR2HCAR3CYP3A4 | |
| SCHEMBL11480358 | 0.98 | KCNH2 (0.39) | KCNH2GPR84HCAR2HCAR3CYP3A4 | |
| SCHEMBL7812120 | 0.98 | KCNH2 (0.39) | KCNH2GPR84HCAR2HCAR3CYP3A4 | |
| SCHEMBL5991669 | 0.93 | — | — | |
| SCHEMBL16673289 | 0.89 | L3MBTL1 (0.37) | L3MBTL1ALDH1A1 | |
| SCHEMBL9633268 | 0.88 | EPHX2 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107286133-B | Application of -5 (the 4H)-thioketones imines of 3- aryl -1,2,4- triazole as NA inhibitor | 湖南大学 | 2019-05-10 | — | — | CN | claimed |
| CN-107286133-A | (4H) the thioketones imines of 3 aryl, 1,2,4 triazole 5 as NA inhibitor application | 湖南大学 | 2017-10-24 | — | — | CN | claimed |
| US-4814112-A | Single-stage process for preparing mixed-substituted 1,2-diacyl-sn-clycero-3-phosphocholines | CL PHARMA AKTIENGESELLSCHAFT (AT) | 1989-03-21 | — | — | US | claimed |
| US-20250215572-A1 | SURFACE TREATMENT AGENT FOR COPPER OR COPPER ALLOY | SHIKOKU CHEMICALS CORPORATION (JP) | 2025-07-03 | — | — | US | disclosed |
| EP-4506488-A1 | SURFACE TREATMENT AGENT FOR COPPER OR COPPER ALLOY | Shikoku Chemicals Corporation (JP) | 2025-02-12 | — | — | EP | disclosed |
| CN-118922584-A | Surface treating agent for copper or copper alloy | 四国化成工业株式会社 | 2024-11-08 | — | — | CN | disclosed |
| WO-2023190263-A1 | SURFACE TREATMENT AGENT FOR COPPER OR COPPER ALLOY | 四国化成工業株式会社 | 2023-10-05 | — | — | WO | disclosed |
| EP-3834828-B1 | COMPOSITION COMPRISING A THIAMINE DERIVATIVE FOR USE IN THE PREVENTION OR TREATMENT OF VASCULAR OR CARDIAC VALVE CALCIFICATION | KYUNGPOOK NAT UNIV IND ACADEMIC COOP FOUND (KR) | 2022-06-08 | — | — | EP | disclosed |
| US-11331317-B2 | Composition for treating vascular or cardiac valvular calcification, containing thiamine derivative | KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION (KR) | 2022-05-17 | — | — | US | disclosed |
| US-20210290621-A1 | COMPOSITION FOR PREVENTING OR TREATING VASCULAR OR CARDIAC VALVULAR CALCIFICATION, CONTAINING THIAMINE DERIVATIVE | PRIMEMUPHARMA CO., LTD (KR) | 2021-09-23 | — | — | US | disclosed |
| EP-3834828-A1 | COMPOSITION FOR PREVENTING OR TREATING VASCULAR OR CARDIAC VALVULAR CALCIFICATION, CONTAINING THIAMINE DERIVATIVE | Kyungpook National University Industry-Academic Cooperation Foundation (KR) | 2021-06-16 | — | — | EP | disclosed |
| WO-1996018618-A1 | 3-ARYL-1,2,4-TRIAZOLE DERIVATIVES WITH HERBICIDAL PROPERTIES | BAYER AKTIENGESELLSCHAFT (DE) | 1996-06-20 | — | — | WO | disclosed |
| US-4888350-A | ANTIFERTILITY AGENTS | GRUPPO LEPETIT S.P.A. (IT) | 1989-12-19 | — | — | US | disclosed |
| US-4888350-A | ANTIFERTILITY AGENTS | GRUPPO LEPETIT S.P.A. (IT) | 1989-12-19 | — | — | US | disclosed |
| US-4888350-A | ANTIFERTILITY AGENTS | GRUPPO LEPETIT S.P.A. (IT) | 1989-12-19 | — | — | US | disclosed |
| US-4459302-A | CONTRACEPTIVES | GRUPPO LEPETIT, S.P.A. (IT) | 1984-07-10 | — | — | US | disclosed |
| US-4459302-A | CONTRACEPTIVES | GRUPPO LEPETIT, S.P.A. (IT) | 1984-07-10 | — | — | US | disclosed |
| US-4459302-A | CONTRACEPTIVES | GRUPPO LEPETIT, S.P.A. (IT) | 1984-07-10 | — | — | US | disclosed |
| US-4069035-A | PLANT GROWTH REGULATORS, PICRATE DYES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1978-01-17 | — | — | US | disclosed |
| US-4038285-A | BUFFER SOLUTIONS, PICRATE DYES, PLANT GROWTH REGULATORS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1977-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210290621-A1 | COMPOSITION FOR PREVENTING OR TREATING VASCULAR OR CARDIAC VALVULAR CALCIFICATION, CONTAINING THIAMINE DERIVATIVE | SLC19A2, FABP3, SLC5A6 | KCNH2 421/4885GPR84 4014/4885HCAR2 1009/4885 |
| US-11331317-B2 | Composition for treating vascular or cardiac valvular calcification, containing thiamine derivative | SLC19A2, VDR, SLC5A6 | KCNH2 385/4885GPR84 3533/4885HCAR2 1100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.