Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.42 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | PKM | P14618 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.39 |
| ▸ | MAPT | P10636 | 8/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | CASP1 | P29466 | 2/20 | 0.39 |
| ▸ | CASP7 | P55210 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10180692 | 0.85 | MAPK8 (0.38) | LMNAHPGDSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL10180469 | 0.85 | MEN1 (0.41) | MEN1KMT2ALMNAHPGDSMN1; SMN2 | |
| SCHEMBL10180598 | 0.83 | MAPK8 (0.45) | MAPK8MAPK9 | |
| SCHEMBL12946841 | 0.82 | MEN1 (0.48) | MEN1KMT2ALMNAHPGDSMN1; SMN2 | |
| SCHEMBL10181025 | 0.74 | MEN1 (0.45) | MEN1KMT2ALMNAHPGDSMN1; SMN2 | |
| SCHEMBL964955 | 0.74 | MEN1 (0.48) | MEN1KMT2ALMNAHPGDSMN1; SMN2 | |
| SCHEMBL10180785 | 0.73 | PIK3CD (0.37) | LMNASMN1; SMN2MAPTKDM4ECYP1A2 | |
| SCHEMBL10181206 | 0.72 | MEN1 (0.47) | MEN1KMT2ALMNAHPGDSMN1; SMN2 | |
| SCHEMBL10181273 | 0.71 | PIK3CD (0.37) | ALDH1A1RXFP1MAPK8MAPK9 | |
| SCHEMBL965134 | 0.71 | ADORA1 (0.38) | HTTMAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | claimed |