Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | CASP1 | P29466 | 2/20 | 0.36 |
| ▸ | CASP7 | P55210 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL965134 | 0.88 | ADORA1 (0.38) | ADORA1ADORA2AHDAC8 | |
| SCHEMBL10180924 | 0.85 | MAPK8 (0.42) | ADORA1ADORA2A | |
| SCHEMBL10181000 | 0.85 | MEN1 (0.42) | MEN1KMT2ALMNAHPGDPKM | |
| SCHEMBL10180124 | 0.84 | MEN1 (0.46) | MEN1KMT2ALMNAHPGDPKM | |
| SCHEMBL10180187 | 0.81 | PIK3CD (0.36) | MEN1KMT2ALMNAHPGDPKM | |
| SCHEMBL10180785 | 0.76 | PIK3CD (0.37) | LMNASMN1; SMN2MAPTRXFP1CYP1A2 | |
| SCHEMBL10180844 | 0.74 | MAPK8 (0.43) | ALDH1A1 | |
| SCHEMBL12947032 | 0.73 | ALDH1A1 (0.35) | MEN1KMT2ALMNAHPGDPKM | |
| SCHEMBL10181273 | 0.73 | PIK3CD (0.37) | RXFP1ADORA1ALDH1A1 | |
| SCHEMBL12946855 | 0.73 | NPC1 (0.40) | LMNAHPGDMAPTADORA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | claimed |