Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 6/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | GCGR | P47871 | 1/20 | 0.33 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.33 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.33 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.33 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | SENP5 | Q96HI0 | 1/20 | 0.32 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.32 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3059771 | 0.90 | LOXL2 (0.40) | LOXL2PTGDR2KDM4EALDH1A1MAPT | |
| SCHEMBL3060418 | 0.86 | HTR2C (0.36) | PTGDR2HRH3KCNQ3KCNQ2KCNE1 | |
| SCHEMBL3056040 | 0.84 | LOXL2 (0.43) | LOXL2HRH3KDM4EMAPTTSHR | |
| SCHEMBL3058094 | 0.84 | LOXL2 (0.44) | LOXL2PTGDR2KCNQ3KCNQ2KCNE1 | |
| SCHEMBL3061116 | 0.82 | HRH3 (0.37) | HRH3KDM4EUSP2ALDH1A1MAPT | |
| SCHEMBL3056414 | 0.79 | MEN1 (0.48) | KDM4EUSP2ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL3067957 | 0.78 | KCNQ3 (0.47) | PTGDR2KCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL3065126 | 0.76 | GAA (0.39) | KDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL3045763 | 0.74 | KCNQ3 (0.44) | PTGDR2GCGRKCNQ3KCNQ2KCNE1 | |
| SCHEMBL3061812 | 0.74 | HIF1A (0.53) | LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2207773-B1 | HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF | OTSUKA PHARMA CO LTD (JP) | 2012-07-11 | — | — | EP | disclosed |