Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | RPS27 | P42677 | 3/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12947087 | 0.94 | MAPK8 (0.38) | ALDH1A1KMT2AMEN1POLBCYP1A2 | |
| SCHEMBL3459965 | 0.94 | MAPK8 (0.39) | ALDH1A1KMT2AMEN1POLBCYP1A2 | |
| SCHEMBL968111 | 0.93 | MAPK8 (0.37) | ALDH1A1KMT2AMEN1POLBCYP1A2 | |
| SCHEMBL10181048 | 0.93 | TRPV4 (0.40) | ALDH1A1KMT2AMEN1POLBCYP1A2 | |
| SCHEMBL968114 | 0.92 | HDAC4 (0.40) | ALDH1A1KMT2AMEN1POLBCYP1A2 | |
| SCHEMBL964495 | 0.92 | CA1 (0.43) | ALDH1A1KMT2AMEN1POLBCYP1A2 | |
| SCHEMBL963866 | 0.91 | HDAC4 (0.41) | ALDH1A1KMT2AMEN1POLBCYP1A2 | |
| SCHEMBL10181891 | 0.90 | MEN1 (0.41) | ALDH1A1KMT2AMEN1POLBCYP1A2 | |
| SCHEMBL3459305 | 0.90 | LCK (0.39) | ALDH1A1KMT2AMEN1POLBCYP1A2 | |
| SCHEMBL967914 | 0.90 | MAPT (0.40) | ALDH1A1KMT2AMEN1POLBCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | claimed |
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | disclosed |