Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 8/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.38 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.38 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12947395 | 0.94 | TRPV4 (0.41) | TRPV4SMN1; SMN2POLBALDH1A1KMT2A | |
| SCHEMBL10181069 | 0.93 | ALDH1A1 (0.39) | TRPV4SMN1; SMN2POLBALDH1A1KMT2A | |
| SCHEMBL964486 | 0.91 | CA1 (0.44) | TRPV4SMN1; SMN2POLBMAPTKDM4E | |
| SCHEMBL3459884 | 0.89 | LCK (0.38) | SMN1; SMN2POLBALDH1A1KMT2AMEN1 | |
| SCHEMBL10180845 | 0.88 | SMN1; SMN2 (0.45) | TRPV4SMN1; SMN2POLBALDH1A1KMT2A | |
| SCHEMBL12947087 | 0.87 | MAPK8 (0.38) | SMN1; SMN2POLBALDH1A1KMT2AMEN1 | |
| SCHEMBL3459965 | 0.87 | MAPK8 (0.39) | TRPV4SMN1; SMN2POLBALDH1A1KMT2A | |
| SCHEMBL12947085 | 0.86 | KDM4E (0.41) | SMN1; SMN2POLBALDH1A1KMT2AMEN1 | |
| SCHEMBL968111 | 0.85 | MAPK8 (0.37) | SMN1; SMN2POLBALDH1A1KMT2AMEN1 | |
| SCHEMBL964485 | 0.84 | SMN1; SMN2 (0.37) | SMN1; SMN2POLBALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | claimed |
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | disclosed |