Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.49 |
| ▸ | JAK3 | P52333 | 2/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | PBK | Q96KB5 | 2/20 | 0.42 |
| ▸ | NUDT1 | P36639 | 5/20 | 0.41 |
| ▸ | PRKCI | P41743 | 4/20 | 0.40 |
| ▸ | AKT2 | P31751 | 3/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.38 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 2/20 | 0.35 |
| ▸ | CHUK | O15111 | 2/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PAK4 | O96013 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29540432 | 0.81 | PRKCI (0.56) | JAK2JAK3JAK1PBKNUDT1 | |
| SCHEMBL100067 | 0.81 | PRKCI (0.56) | JAK2JAK3JAK1PBKNUDT1 | |
| SCHEMBL1723771 | 0.74 | JAK2 (0.61) | JAK2JAK3JAK1NUDT1PRKCI | |
| Trifluoroacetic Acid SCHEMBL4096039 | 0.73 | PRKCI (0.47) | JAK2JAK3JAK1PBKNUDT1 | |
| SCHEMBL1723802 | 0.70 | JAK2 (0.55) | JAK2JAK3JAK1NUDT1PRKCI | |
| SCHEMBL16720285 | 0.69 | NUDT1 (0.51) | JAK2JAK3PBKNUDT1PRKCI | |
| SCHEMBL29541478 | 0.67 | PRKCI (0.53) | JAK2JAK3JAK1PBKNUDT1 | |
| SCHEMBL102287 | 0.67 | PRKCI (0.53) | JAK2JAK3JAK1PBKNUDT1 | |
| SCHEMBL98619 | 0.66 | PRKCI (0.56) | JAK2JAK3PBKNUDT1PRKCI | |
| SCHEMBL29541300 | 0.66 | PRKCI (0.56) | JAK2JAK3PBKNUDT1PRKCI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2474545-A1 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | Incyte Corporation (US) | 2012-07-11 | — | — | EP | disclosed |