Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.55 |
| ▸ | JAK3 | P52333 | 2/20 | 0.55 |
| ▸ | JAK1 | P23458 | 1/20 | 0.55 |
| ▸ | IKBKB | O14920 | 4/20 | 0.51 |
| ▸ | CHUK | O15111 | 4/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.51 |
| ▸ | IGF1R | P08069 | 2/20 | 0.51 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | PAK4 | O96013 | 1/20 | 0.51 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.51 |
| ▸ | PRKACA | P17612 | 1/20 | 0.51 |
| ▸ | FLT1 | P17948 | 1/20 | 0.51 |
| ▸ | LTK | P29376 | 1/20 | 0.51 |
| ▸ | GRK5 | P34947 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1723771 | 0.95 | JAK2 (0.61) | JAK2JAK3JAK1IKBKBCHUK | |
| SCHEMBL10124857 | 0.79 | CDK9 (0.49) | JAK2JAK3IKBKBCHUKAURKB | |
| SCHEMBL2240671 | 0.77 | AURKB (0.71) | JAK2JAK3IKBKBCHUKAURKB | |
| SCHEMBL4062740 | 0.75 | JAK3 (0.91) | JAK2JAK3JAK1IKBKBCHUK | |
| SCHEMBL4412860 | 0.73 | DYRK1A (0.51) | JAK2JAK3JAK1DAPK3MAP4K4 | |
| SCHEMBL1726149 | 0.72 | JAK3 (0.51) | JAK2JAK3JAK1KDRDYRK1A | |
| SCHEMBL14493878 | 0.71 | CCNT1 (0.50) | JAK3JAK1AURKBMAP4K4FGFR1 | |
| SCHEMBL13961115 | 0.71 | JAK3 (1.00) | JAK2JAK3JAK1IKBKBCHUK | |
| SCHEMBL12346363 | 0.71 | AURKB (0.47) | JAK2JAK3IKBKBCHUKAURKB | |
| SCHEMBL27819451 | 0.70 | HTR1A (0.46) | JAK1AURKBCDK9NUDT1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3070086-B1 | AZAINDOLE DERIVATIVE | TAIHO PHARMACEUTICAL CO LTD (JP) | 2018-11-21 | — | — | EP | disclosed |
| US-9782392-B2 | Azaindole derivative | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2017-10-10 | — | — | US | disclosed |
| US-9782392-B2 | Azaindole derivative | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2017-10-10 | — | — | US | disclosed |
| US-9782392-B2 | Azaindole derivative | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2017-10-10 | — | — | US | disclosed |
| US-9676773-B2 | Azaindole derivative | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2017-06-13 | — | — | US | disclosed |
| US-9676773-B2 | Azaindole derivative | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2017-06-13 | — | — | US | disclosed |
| US-9676773-B2 | Azaindole derivative | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2017-06-13 | — | — | US | disclosed |
| US-20170119743-A1 | AZAINDOLE DERIVATIVE | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2017-05-04 | — | — | US | disclosed |
| US-20170119743-A1 | AZAINDOLE DERIVATIVE | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2017-05-04 | — | — | US | disclosed |
| US-20170119743-A1 | AZAINDOLE DERIVATIVE | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2017-05-04 | — | — | US | disclosed |
| US-8921376-B2 | Pyrrolopyridines useful as inhibitors of protein kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-12-30 | — | — | US | disclosed |
| EP-1881983-B1 | PYRROLOPYRIDINES USEFUL AS INHIBITORS OF PROTEIN KINASE | VERTEX PHARMA (US) | 2012-01-11 | — | — | EP | disclosed |
| EP-1881983-B1 | PYRROLOPYRIDINES USEFUL AS INHIBITORS OF PROTEIN KINASE | VERTEX PHARMA (US) | 2012-01-11 | — | — | EP | disclosed |
| EP-2354139-A1 | Pyrrolopyridines useful as inhibitors of protein kinase | Vertex Pharmaceuticals Incorporated (US) | 2011-08-10 | — | — | EP | disclosed |
| EP-2354140-A1 | Pyrrolopyridines useful as inhibitors of protein kinase | Vertex Pharmaceuticals Incorporated (US) | 2011-08-10 | — | — | EP | disclosed |
| EP-1881983-A1 | PYRROLOPYRIDINES USEFUL AS INHIBITORS OF PROTEIN KINASE | Vertex Pharmaceuticals, Inc. (US) | 2008-01-30 | — | — | EP | disclosed |
| US-20070135466-A1 | Pyrrolopyridines useful as inhibitors of protein kinase | VERTEX PHARMACEUTICALS INCORPORATED | 2007-06-14 | — | — | US | disclosed |
| US-20070135466-A1 | Pyrrolopyridines useful as inhibitors of protein kinase | VERTEX PHARMACEUTICALS INCORPORATED | 2007-06-14 | — | — | US | disclosed |
| US-20070135466-A1 | Pyrrolopyridines useful as inhibitors of protein kinase | VERTEX PHARMACEUTICALS INCORPORATED | 2007-06-14 | — | — | US | disclosed |
| WO-2006127587-A1 | PYRROLOPYRIDINES USEFUL AS INHIBITORS OF PROTEIN KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-11-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170119743-A1 | AZAINDOLE DERIVATIVE | JAK3, JAK1, JAK2 | JAK2 3/4885JAK3 1/4885JAK1 2/4885 |
| US-20070135466-A1 | Pyrrolopyridines useful as inhibitors of protein kinase | JAK2, JAK1, JAK3 | JAK2 1/4885JAK3 3/4885JAK1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.