Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 3/20 | 0.38 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10182997 | 0.86 | CYP2C19 (0.40) | CYP2C19ALDH1A1SIGMAR1CYP2D6HRH3 | |
| SCHEMBL10235007 | 0.77 | CYP2C19 (0.41) | ALOX15CYP3A4CYP2C19ALDH1A1SIGMAR1 | |
| SCHEMBL2824676 | 0.74 | CYP2C19 (0.44) | CYP3A4CYP2C19ALDH1A1CNR2L3MBTL1 | |
| SCHEMBL2826040 | 0.71 | HCRTR1 (0.46) | ALOX15CYP3A4CYP2C19ALDH1A1CNR2 | |
| SCHEMBL21978852 | 0.71 | FYN (0.44) | ALOX15CYP3A4CYP2C19ALDH1A1CYP2D6 | |
| SCHEMBL12997491 | 0.70 | ALDH1A1 (0.37) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL31326491 | 0.69 | ALDH1A1 (0.46) | ALOX15CYP3A4CYP2C19ALDH1A1CXCR4 | |
| SCHEMBL30660164 | 0.68 | AURKA (0.48) | ALOX15CYP3A4CYP2C19ALDH1A1CXCR4 | |
| SCHEMBL24453628 | 0.68 | ALOX15 (0.48) | ALOX15CYP3A4CYP2C19CNR2CXCR4 | |
| SCHEMBL26351869 | 0.68 | SMN1; SMN2 (0.51) | ALOX15CYP3A4CYP2C19ALDH1A1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120040951-A1 | HETEROARYL COMPOUNDS USEFUL AS RAF KINASE INHIBITORS | SUNESIS PHARMACEUTICALS, INC. | 2012-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040951-A1 | HETEROARYL COMPOUNDS USEFUL AS RAF KINASE INHIBITORS | BRAF, RAF1, ARAF | ALOX15 3361/4885CYP3A4 3520/4885CYP2C19 3284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.