Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CCKBR | P32239 | 7/20 | 0.37 |
| ▸ | CCKAR | P32238 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10184154 | 0.87 | POLB (0.39) | ALDH1A1HSD17B10MEN1KMT2APOLB | |
| SCHEMBL10185945 | 0.86 | OPRM1 (0.39) | ALDH1A1POLBCCKBRCCKAROPRM1 | |
| SCHEMBL10185926 | 0.85 | OPRM1 (0.39) | ALDH1A1POLBHTTLMNAMAPT | |
| SCHEMBL10183666 | 0.85 | OPRM1 (0.39) | ALDH1A1POLBHTTLMNAMAPT | |
| SCHEMBL10184153 | 0.85 | OPRM1 (0.39) | HPGDPOLBOPRM1OPRK1OPRL1 | |
| SCHEMBL10185544 | 0.82 | OPRM1 (0.40) | ALDH1A1POLBLMNAMAPTOPRM1 | |
| SCHEMBL10185925 | 0.81 | MEN1 (0.39) | ALDH1A1HSD17B10MEN1KMT2APOLB | |
| SCHEMBL10183731 | 0.81 | USP2 (0.39) | ALDH1A1HSD17B10HPGDKDM4EMEN1 | |
| SCHEMBL10185950 | 0.81 | SMN1; SMN2 (0.39) | ALDH1A1HSD17B10HPGDKDM4EMEN1 | |
| SCHEMBL10183972 | 0.80 | OPRM1 (0.36) | ALDH1A1HPGDMEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012009678-A1 | THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHOD OF USE | AGIOS PHARMACEUTICALS, INC. (US) | 2012-01-19 | — | — | WO | disclosed |