Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10185945 | 0.90 | OPRM1 (0.39) | POLBALDH1A1OPRM1OPRK1OPRD1 | |
| SCHEMBL10184153 | 0.88 | OPRM1 (0.39) | POLBOPRM1OPRK1OPRD1SIGMAR1 | |
| SCHEMBL10185926 | 0.88 | OPRM1 (0.39) | POLBALDH1A1HTTOPRM1OPRK1 | |
| SCHEMBL10183666 | 0.88 | OPRM1 (0.39) | POLBALDH1A1HTTOPRM1OPRK1 | |
| SCHEMBL10183727 | 0.87 | ALDH1A1 (0.41) | POLBALDH1A1MEN1ESR1ALOX15 | |
| SCHEMBL10185544 | 0.86 | OPRM1 (0.40) | POLBALDH1A1OPRM1OPRK1OPRD1 | |
| SCHEMBL10185925 | 0.85 | MEN1 (0.39) | POLBALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL10183731 | 0.84 | USP2 (0.39) | POLBALDH1A1MEN1ALOX15HTT | |
| SCHEMBL10185950 | 0.84 | SMN1; SMN2 (0.39) | POLBALDH1A1MEN1ALOX15HTT | |
| SCHEMBL10183220 | 0.84 | CHRM2 (0.36) | POLBALDH1A1MEN1ESR1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012009678-A1 | THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHOD OF USE | AGIOS PHARMACEUTICALS, INC. (US) | 2012-01-19 | — | — | WO | disclosed |