Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | ESR1 | P03372 | 7/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11351335 | 0.80 | ESR1 (0.52) | TSHRSMN1; SMN2CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL10184009 | 0.78 | HDAC1 (0.41) | TSHRSMN1; SMN2MAPTCYP1A2ALDH1A1 | |
| SCHEMBL11685042 | 0.78 | HPGD (0.51) | TSHRSMN1; SMN2CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL10184749 | 0.76 | ALDH1A1 (0.45) | TSHRSMN1; SMN2MAPTCYP1A2CYP2C19 | |
| SCHEMBL19076019 | 0.75 | SMN1; SMN2 (0.44) | TSHRSMN1; SMN2MAPTALDH1A1HPGD | |
| SCHEMBL10184741 | 0.75 | CDK1 (0.41) | TSHRSMN1; SMN2MAPTCYP1A2CYP2C19 | |
| SCHEMBL9915414 | 0.73 | TSHR (0.54) | TSHRSMN1; SMN2MAPTCYP1A2CYP2C19 | |
| SCHEMBL13275435 | 0.73 | HDAC1 (0.36) | SMN1; SMN2MAPTALDH1A1HPGDKDM4E | |
| SCHEMBL10184767 | 0.72 | MAPT (0.46) | TSHRSMN1; SMN2MAPTCYP1A2CYP2C19 | |
| SCHEMBL10184780 | 0.72 | TSHR (0.48) | TSHRSMN1; SMN2MAPTCYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120040951-A1 | HETEROARYL COMPOUNDS USEFUL AS RAF KINASE INHIBITORS | SUNESIS PHARMACEUTICALS, INC. | 2012-02-16 | — | — | US | disclosed |
| WO-2010078408-A1 | HETEROARYL COMPOUNDS USEFUL AS RAF KINASE INHIBITORS | BIOGEN IDEC MA INC. (US) | 2010-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040951-A1 | HETEROARYL COMPOUNDS USEFUL AS RAF KINASE INHIBITORS | BRAF, RAF1, ARAF | TSHR 2976/4885SMN1; SMN2 4529/4885MAPT 4105/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.