Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 9/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | GABRP | O00591 | 1/20 | 0.44 |
| ▸ | GABRD | O14764 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9915360 | 0.84 | KDM4E (0.47) | TSHRCYP1A2MAPTALDH1A1CYP3A4 | |
| SCHEMBL9915365 | 0.83 | MAPT (0.44) | TSHRSMN1; SMN2CYP1A2CYP2C19MAPT | |
| SCHEMBL9915498 | 0.83 | KDM4E (0.44) | TSHRSMN1; SMN2CYP1A2CYP2C19MAPT | |
| SCHEMBL27449890 | 0.78 | TSHR (0.60) | TSHRSMN1; SMN2CYP1A2CYP2C19MAPT | |
| SCHEMBL18417204 | 0.76 | TSHR (0.65) | TSHRSMN1; SMN2CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL9915460 | 0.76 | CYP1A2 (0.38) | SMN1; SMN2CYP1A2CYP2C19MAPTALDH1A1 | |
| SCHEMBL9915472 | 0.76 | BACE1 (0.41) | SMN1; SMN2CYP1A2CYP2C19CYP2C9LMNA | |
| SCHEMBL9915408 | 0.76 | EGLN1 (0.45) | MAPTALDH1A1HPGDKDM4ELMNA | |
| SCHEMBL9915407 | 0.76 | POLB (0.44) | SMN1; SMN2MAPTALDH1A1HPGDKDM4E | |
| SCHEMBL3712576 | 0.75 | ESR1 (0.50) | TSHRSMN1; SMN2CYP1A2CYP2C19MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150148326-A1 | Monobactams | PFIZER (US) | 2015-05-28 | — | — | US | disclosed |
| EP-2646436-B1 | MONOBACTAMS | PFIZER (US) | 2015-05-27 | — | — | EP | disclosed |
| US-20130252935-A1 | Monobactams | PFIZER INC. (US) | 2013-09-26 | — | — | US | disclosed |
| US-20120302542-A1 | MONOBACTAMS | PFIZER INC | 2012-11-29 | — | — | US | disclosed |
| WO-2012073138-A1 | MONOBACTAMS | PFIZER INC. (US) | 2012-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130252935-A1 | Monobactams | MGAM, MGAM2, BPGM | TSHR 4478/4885SMN1; SMN2 4574/4885CYP1A2 957/4885 |
| US-20150148326-A1 | Monobactams | MGAM, MGAM2, BPGM | TSHR 4478/4885SMN1; SMN2 4574/4885CYP1A2 957/4885 |
| US-20120302542-A1 | MONOBACTAMS | MGAM, MGAM2, BPGM | TSHR 4478/4885SMN1; SMN2 4574/4885CYP1A2 957/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.