Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.52 |
| ▸ | GSK3B | P49841 | 3/20 | 0.43 |
| ▸ | GSK3A | P49840 | 2/20 | 0.43 |
| ▸ | PAK4 | O96013 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 12/20 | 0.42 |
| ▸ | ULK1 | O75385 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3023036 | 0.79 | TGFBR1 (0.53) | PAK4CDK2JAK1 | |
| SCHEMBL1018558 | 0.74 | PTK2 (0.57) | PAK4 | |
| SCHEMBL30355999 | 0.74 | JAK1 (0.56) | JAK1 | |
| SCHEMBL20917977 | 0.74 | JAK1 (0.56) | JAK1 | |
| SCHEMBL1554031 | 0.72 | ROCK2 (0.67) | ROCK2GSK3BGSK3APAK4CDK2 | |
| SCHEMBL1071001 | 0.71 | ADORA1 (0.56) | PAK4JAK1 | |
| SCHEMBL2018511 | 0.70 | ADORA1 (0.44) | PAK4JAK1 | |
| SCHEMBL22975471 | 0.69 | HPGDS (0.60) | PAK4JAK1 | |
| SCHEMBL1018595 | 0.69 | HPGDS (0.56) | PAK4JAK1 | |
| SCHEMBL22497061 | 0.68 | PAK4 (0.46) | PAK4CDK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271631-A2 | INHIBITORS OF PROTEIN KINASES | Portola Pharmaceuticals, Inc. (US) | 2011-01-12 | — | — | EP | disclosed |
| WO-2009131687-A2 | INHIBITORS OF PROTEIN KINASES | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-10-29 | — | — | WO | disclosed |