⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27470766 | 0.89 | ADH1B (0.40) | — | |
| SCHEMBL1462382 | 0.82 | — | — | |
| SCHEMBL1462485 | 0.80 | — | — | |
| SCHEMBL1462499 | 0.78 | EPHX1 (0.58) | — | |
| SCHEMBL988701 | 0.78 | EPHX1 (0.58) | — | |
| SCHEMBL23929272 | 0.78 | EPHX1 (0.58) | — | |
| SCHEMBL3366462 | 0.78 | EPHX1 (0.58) | — | |
| SCHEMBL8956839 | 0.78 | EPHX1 (0.58) | — | |
| SCHEMBL10809979 | 0.78 | EPHX1 (0.58) | — | |
| SCHEMBL28313279 | 0.78 | TSHR (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 90 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110071084-A1 | BENZAZEPINE DERIVATIVES USEFUL AS VASOPRESSIN ANTAGONISTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2011-03-24 | — | — | US | claimed |
| EP-2170831-A1 | BENZAZEPINE DERIVATIVES USEFUL AS VASOPRESSIN ANTAGONISTS | Otsuka Pharmaceutical Co., Ltd. (JP) | 2010-04-07 | — | — | EP | claimed |
| WO-2009001968-A1 | BENZAZEPINE DERIVATIVES USEFUL AS VASOPRESSIN ANTAGONISTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-12-31 | — | — | WO | claimed |
| EP-1678146-A1 | PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | Pharmacia Corporation (US) | 2006-07-12 | — | — | EP | claimed |
| EP-1678164-A1 | SUBSTITUTED PYRAZINONE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | Pharmacia Corporation (US) | 2006-07-12 | — | — | EP | claimed |
| WO-2005040133-A1 | PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2005-05-06 | — | — | WO | claimed |
| WO-2005035527-A1 | SUBSTITUTED PYRAZINONE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2005-04-21 | — | — | WO | claimed |
| EP-0002822-B1 | PHOSPHORUS CONTAINING PEPTIDE DERIVATIVES, THEIR PRODUCTION, INTERMEDIATES FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-07-28 | — | — | EP | claimed |
| US-20240216389-A1 | DRUG FOR PREVENTING AND/OR TREATING POLYCYSTIC KIDNEY DISEASE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2024-07-04 | — | — | US | disclosed |
| US-11957691-B2 | Drug for preventing and/or treating polycystic kidney disease | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2024-04-16 | — | — | US | disclosed |
| US-20230330258-A1 | CONJUGATES COMPRISING A PHOSPHORUS (V) AND A DRUG MOIETY | TUBULIS GMBH (DE) | 2023-10-19 | — | — | US | disclosed |
| US-11147821-B2 | Drug for preventing and/or treating polycystic kidney disease | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2021-10-19 | — | — | US | disclosed |
| US-11013746-B2 | Drug for preventing and/or treating polycystic kidney disease | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2021-05-25 | — | — | US | disclosed |
| US-20190117666-A1 | DRUG FOR PREVENTING AND/OR TREATING POLYCYSTIC KIDNEY DISEASE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2019-04-25 | — | — | US | disclosed |
| US-4018787-A | HERBICIDES | VELSICOL CHEMICAL CORPORATION (US) | 1977-04-19 | — | — | US | disclosed |
| US-4012223-A | Thiadiazolylimidazolidinones herbicides | VELSICOL CHEMICAL CORPORATION (US) | 1977-03-15 | — | — | US | disclosed |
| US-4008068-A | HERBICIDE | VELSICOL CHEMICAL CORPORATION (US) | 1977-02-15 | — | — | US | disclosed |
| US-3990882-A | HERBICIDES | VELSICOL CHEMICAL CORPORATION (US) | 1976-11-09 | — | — | US | disclosed |
| US-3944409-A | Method of increasing the yield of plants having storage organs by treatment with thiadiazolylimidazolines | VELSICOL CHEMICAL CORPORATION (US) | 1976-03-16 | — | — | US | disclosed |
| US-3933839-A | HERBICIDES | VELSICOL CHEMICAL CORPORATION (US) | 1976-01-20 | — | — | US | disclosed |